Sökning: "imaging mass spectrometry"

Visar resultat 16 - 20 av 90 avhandlingar innehållade orden imaging mass spectrometry.

  1. 16. Imaging mass spectrometry for in situ lipidomics: from cell structures to cardiac tissue

    Författare :Sanna Sämfors; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Myocardial infarction; PC12 cells; Cell membrane; Mass spectrometry imaging; Sample preparation; Lipidomics; ToF-SIMS; Gas cluster ion beam;

    Sammanfattning : Imaging of cells and tissues is important for studying different processes within biological systems due to the spatial information provided for different molecular species during imaging. One powerful imaging technique is mass spectrometry imaging (MSI). LÄS MER

  3. 17. Mass Spectrometry-Based Protein Biomarker Discovery in Pancreatic Cancer

    Författare :Qimin Zhou; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; proteomics; mass spectrometry; biomarkers; diagnosis; prognosis; prediction; BASP1; WT1; YAP1; AGP1;

    Sammanfattning : Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. LÄS MER

  4. 18. Cerebrum Illuminans : Mass Spectrometric Analysis of Protein and Peptide Dynamics in Neurological Diseases

    Författare :Jörg Hanrieder; Jonas Bergquist; Malin Andersson; Ulf Hellman; Alma Burlingame; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; central nervous system; neurological disease; proteomics; MALDI imaging; Analytical chemistry; Analytisk kemi; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : The human brain (lat. cerebrum) is the most complex and heterogeneous organ in the human body. It is involved in a great number of body functions like movement, touch sensing, vision, hearing, smelling, hormone regulation and many more. In no other organ, the molecular communication mechanisms between different cells are so poorly understood. LÄS MER

  5. 19. Imaging neurochemical changes associated with Parkinson´s disease and L-DOPA-induced dyskinesia using mass spectrometry

    Författare :Elva Fridjonsdottir; Per E. Andrén; Miles Trupp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; Parkinson´s disease; L-DOPA-induced dyskinesia;

    Sammanfattning : Parkinson’s disease (PD), caused by a loss of midbrain dopamine neurons, is the second most common neurodegenerative disease worldwide after Alzheimer’s disease. The primary treatment choice for PD is L-DOPA, the precursor for dopamine, which only affects symptoms and does not inhibit disease progression. LÄS MER

  7. 20. Algorithms and Methods for Robust Processing and Analysis of Mass Spectrometry Data

    Författare :Jonatan Eriksson; Avdelningen för Biomedicinsk teknik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Algorithms; Signal Processing; Dynamic Programming; Biomarker discovery; High-dimensional data;

    Sammanfattning : Liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) are two techniques that are routinely used to study proteins, peptides, and metabolites at a large scale. Thousands of biological compounds can be identified and quantified in a single experiment with LC-MS, but many studies fail to convert this data to a better understanding of disease biology. LÄS MER