Sökning: "imaging mass spectrometry"

Visar resultat 1 - 5 av 60 avhandlingar innehållade orden imaging mass spectrometry.

  1. 1. Applications of nanospray desorption electrospray ionization mass spectrometry In situ lipid and metabolite analysis from cells to tissue

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Hilde-Marléne Bergman; Uppsala universitet.; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; mass spectrometry imaging MSI ; nanospray desorption electrospray ionization nano-DESI ; single-cell analysis; neurotransmitter imaging; diabetic nephropathy; pneumatic nebulization; lipidomics; metabolomics; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Ambient mass spectrometry (MS) has proved to be an important addition to the bioanalytical toolbox. These methods perform analyte sampling and ionization under atmospheric pressure, and require very little sample preparation other than the sampling process in front of the machine. LÄS MER

  2. 2. Advanced Mass Spectrometry Imaging in Neuropharmacology

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Theodosia Vallianatou; Uppsala universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; neuropharmacology; blood brain barrier; drug-drug interactions; aging; tacrine;

    Sammanfattning : Mass spectrometry imaging (MSI) has emerged as a valuable approach for mapping multiple molecular species in sections of diverse tissues. It enables simultaneous detection of numerous compounds (from neurotransmitters to small proteins) in the brain at relatively high lateral resolution (>5 μm) on a routine basis. LÄS MER

  3. 3. Mass Spectrometry-based Neuroproteomics Deciphering the Human Brain Proteome

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sravani Musunuri; Uppsala universitet.; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Brain; Proteomics; Mass spectrometry; Alzheimer s disease; Traumatic brain injury; Membrane proteins; Sample preparation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Mammalian brain is challenging to study due to its heterogeneity and complexity. However, recent advances in molecular imaging, genomics and proteomics have contributed significantly to achieve insights into molecular basis of brain function and pathogenesis of neurological disorders. LÄS MER

  4. 4. Molecular Profiling and Imaging of Peptides, Proteins and Drugs in Biological Tissue using Mass Spectrometry

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Nilsson; Uppsala universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptidomics; mass spectrometry; liquid chromatography; MALDI imaging; neuropeptides; drugs; brain; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Sammanfattning : Biological functions within cells and organisms are mainly carried out by the translational products; proteins and peptides. The analysis and characterization of these biomolecules are of great importance for the progress in disease research and biomarker and drug discovery. LÄS MER

  5. 5. Development and Application of Software Tools for Mass Spectrometry Imaging

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Patrik Källback; Uppsala universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; DESI; msIQuant; quantitation; neurotransmitters; drugs; derivatization; brain; compression; data entropy reduction;

    Sammanfattning : Mass spectrometry imaging (MSI) has been extensively used to produce qualitative maps of distributions of proteins, peptides, lipids, neurotransmitters, small molecule pharmaceuticals and their metabolites directly in biological tissue sections. Moreover, during the last 10 years, there has been growing demand to quantify target compounds in tissue sections of various organs. LÄS MER