Sökning: "genetic linkage"

Visar resultat 6 - 10 av 291 avhandlingar innehållade orden genetic linkage.

  1. 6. Genetic Studies of Alzheimer's Disease

    Författare :Elin Blom; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Jan Hillert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Linkage; Affected sib-pairs; APOE; APP duplication; 10q21; 19q13; Wnt signaling; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi;

    Sammanfattning : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. LÄS MER

  3. 7. Genetic Disequilibria and the Interpretation of Population Genetic Structure in Daphnia

    Författare :Lars M. Berg; Xavier Vekemans; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; breeding system; linkage disequilibrium; dispersal; genetic structure; Daphnia pulex; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; naturvårdsbiologi; Conservation Biology;

    Sammanfattning : Understanding the processes that shape the spatial distribution of genetic variation within species is central to the evolutionary study of diversification and demography. Neutral genetic variation reflects past demographic events as well as current demographic characteristics of populations, and the correct interpretation of genetic data requires that the relative impact of these forces can be identified. LÄS MER

  4. 8. Linkage maps in studies of genetic variation - examples from Beta vulgaris

    Författare :Thomas Kraft; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytogenetics; Genetics; Beta vulgaris; Linkage maps; genetic variation; Genetik; cytogenetik;

    Sammanfattning : Today, most studies of genetic variation utilise molecular markers, making it possible to detect variation at the DNA level. This has greatly facilitated studies of genetic variation in population and evolutionary genetics, systematics and transmission genetics. LÄS MER

  5. 9. Mapping genetic diseases in northern Sweden

    Författare :Elisabet Einarsdottir; Dan Holmberg; Gösta Holmgren; Ulf Gyllensten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; isolated populations; linkage disequilibrium; linkage analysis; genome-wide scan; hereditary sensory and autonomic neuropathy; type 1 diabetes mellitus; type 2 diabetes mellitus; autoimmune thyroid disease; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : The population of northern Sweden has previously been shown to be well suited for the mapping of monogenic diseases. In this thesis we have tested the hypothesis that this population could also be used for efficient identification of risk genes for common diseases. LÄS MER

  7. 10. Genetic investigations of four neurological disorders : From phenotype to mutation

    Författare :Anna Sillén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; genetic disease; chromosome; microsatellite; linkage analysis; mutation; Pediatrik; Paediatric medicine; Pediatrisk medicin; klinisk genetik; Clinical Genetics;

    Sammanfattning : More than 5000, more or less rare, genetic diseases are known in man. A genetic disease is in most casesinherited from one generation to the next, and is caused by a change in the genetic code, a mutation. LÄS MER