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Visar resultat 21 - 25 av 265 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Contributions to Variable Fidelity MDO Framework for Collaborative and Integrated Aircraft Design

    Författare :Zhang Mengmeng; Arthur Rizzi; Leifsson Leifur; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aerospace Engineering; Flyg- och rymdteknik;

    Sammanfattning : The thesis develops computational tools for early stages of the aircraft design process. The work focuses on a framework which allows several design teams concurrently to develop a baseline concept into a configuration which meets requirements and whose aerodynamics has been assessed by flight simulation. LÄS MER

  3. 22. Data-driven microscopy: placing high-fidelity data in a population-wide context

    Författare :Oscar André; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Data-driven microscopy; Event-driven microscopy; high-content screening; automation; image analysis; data analysis; cell heterogeneity; host-pathogen interactions; Streptococcus pyogenes GAS ; SARS-CoV-2;

    Sammanfattning : Mikroskopi är idag ett fundamentalt verktyg inom forskning, där det tillåter oss att skåda in och utforska våra prover i hög detalj. Mycket utav utvecklingen av nya mikroskopimetoder har strävat efter att öka den detaljnivå vi kan uppnå. LÄS MER

  4. 23. Population structure, movements and site fidelity of grey seals in the Baltic Sea

    Författare :Olle Karlsson; Kit M. Kovacs; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ethology and behavioural ecology; Etologi och beteendeekologi; Animal Ecology; zooekologi;

    Sammanfattning : The management and conservation of wildlife must rely on a solid understanding of key ecological and demographic factors. To devise management and conservation strategies for species affected by human activities it is essential to define populations. LÄS MER

  5. 24. Structural and biochemical basis for the high fidelity and processivity of DNA polymerase ε

    Författare :Rais Ahmad Ganai; Erik Johansson; Per Elias; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase ε; Crystal structure; P domain; Pre-steady state kinetics; β-hairpin loop; Primer switching; Strand displacement; biokemi; Biochemistry;

    Sammanfattning : DNA polymerase epsilon (Pol ε) is a multi-subunit B-family DNA polymerase that is involved in leading strand DNA replication in eukaryotes. DNA Pol ε in yeast consists of four subunits, Pol2, Dpb2, Dpb3, and Dpb4. Pol2 is the catalytic subunit and Dpb2, Dpb3, and Dpb4 are the accessory subunits. LÄS MER

  7. 25. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

    Författare :Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. LÄS MER