Sökning: "Pre-steady state kinetics"
Hittade 5 avhandlingar innehållade orden Pre-steady state kinetics.
1. Structural and biochemical basis for the high fidelity and processivity of DNA polymerase ε
Sammanfattning : DNA polymerase epsilon (Pol ε) is a multi-subunit B-family DNA polymerase that is involved in leading strand DNA replication in eukaryotes. DNA Pol ε in yeast consists of four subunits, Pol2, Dpb2, Dpb3, and Dpb4. Pol2 is the catalytic subunit and Dpb2, Dpb3, and Dpb4 are the accessory subunits. LÄS MER
2. Oxidation of 1,2-Diols Using Alcohol Dehydrogenases : From Kinetic Characterization to Directed Evolution
Sammanfattning : The use of enzymes as catalysts for chemical transformations has emerged as a “greener” alternative to traditional organic synthesis. An issue to solve though, is that enzymes are designed by nature to catalyze reactions in a living cell and therefore, in many cases, do not meet the requirements of a suitable biocatalyst. LÄS MER
3. The kinetic mechanism of microsomal glutathione transferase 1 (MGST1)
Sammanfattning : Microsomal glutathione transferase I (MGST1) is a homotrimeric membrane-bound enzyme involved in detoxication of numerous toxic electrophilic compounds, e.g. halogenated alkenes and arenes, alpha, beta-unsaturated hydrocarbons and peroxides. MGST1 is expressed in large amounts in most organs, which speaks for an important role for this enzyme. LÄS MER
4. Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism
Sammanfattning : The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is a family of six membrane bound proteins with different biological functions. MAPEG superfamily members enable and catalyze reactions where reactive lipid intermediates are either transformed to physiological messengers or turned into unreactive compounds. LÄS MER
5. Mechanism of enzymes involved in leukotriene C4 biosynthesis
Sammanfattning : Cysteinyl leukotrienes (cys-LTs) are potent proinflammatory mediators associated with various diseases including asthma and allergic rhinitis. Leukotriene C4 synthase (LTC4S) and microsomal glutathione transferase 2 (MGST2) catalyze conjugation of the epoxide intermediate LTA4 with GSH to form LTC4, the parent compound of the cys-LTs. LÄS MER