Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

   Författare :Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

   Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER

3. 2. Interplay between tick-borne encephalitis virus and the host innate immunity

   Författare :Chaitanya Kurhade; Anna Överby Wernstedt; Nelson Gekara; Helen Lazear; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Flavivirus; IPS-1; Interferon; Viperin; mikrobiologi; Microbiology;

   Sammanfattning : Flaviviruses are important emerging and re-emerging arthropod-borne pathogens that cause significant morbidity and mortality in humans. It consists of globally distributed human pathogens such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZIKV). LÄS MER

4. 3. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus

   Författare :Koushikul Islam; Clas Ahlm; Magnus Evander; Anna K. Överby; Johan Neyts; Umeå universitet; []
   Nyckelord :Rift Valley fever virus; antiviral; assay development; screening; drug discovery;

   Sammanfattning : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. LÄS MER

5. 4. Ticks and Tick-borne Encephalitis Virus : From Nature to Infection

   Författare :Naveed Asghar; Magnus Johansson; Patrik Dinnétz; Travis Taylor; Södertörns högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-occurrence; Environmental factors; Flavivirus; Ixodes ricinus; Natural foci; Non-coding region; Poly A tract; Quasispecies; Questing ticks; Scandinavia; Tick-borne encephalitis virus; Vegetation.; Environmental Studies; Miljövetenskapliga studier;

   Sammanfattning : Vector-borne diseases are an increasing global threat to humans due to climate changes, elevating the risk of infections transmitted by mosquitos, ticks, and other arthropod vectors. Ixodes ricinus, a common tick in Europe, transmits dangerous tick-borne pathogens to humans. LÄS MER

7. 5. Specifity and genetic control of B cell reactivity in experimental arthritis

   Författare :Patrik Wernhoff; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Genetics; cytogenetics; Genetik; cytogenetik; Immunologi; Autoimmunity B-cell response Epitope Genetics Linkage Analysis; Immunology; serology;

   Sammanfattning : Collagen-induced arthritis (CIA) and pristane-induced arthritis (PIA) are animal models for human rheumatoid arthritis (RA), and can be induced in susceptible mouse and rat strains. CIA is induced by immunization of type II collagen (CII), a cartilage specific protein together with Freund’s adjuvant. LÄS MER