Sökning: "CIAO1"

Hittade 2 avhandlingar innehållade ordet CIAO1.

1. 1. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

   Författare :Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

   Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER

3. 2. Viperin, a multifunctional radical SAM enzyme : biogenesis and antiviral mechanisms

   Författare :Arunkumar Upadhyay; Anna K. Överby; Niklas Arnberg; Richard Lundmark; Michael Beard; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. LÄS MER