Sökning: "Interferon-stimulated gene"

Hittade 5 avhandlingar innehållade orden Interferon-stimulated gene.

  1. 1. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

    Författare :Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER

  3. 2. On the immune response in porcine enteric diseases : with special reference to swine dysentery, proliferative enteropathy and PMWS

    Författare :Märit Andersson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Enteric infectious diseases are a common problem worldwide among pigs. It is important to gain a better knowledge about the pathogeneses of the diseases and the local immune response, in which the intestine has a very important role. LÄS MER

  4. 3. Immunological effects of isolated regional perfusion in malignant melanoma

    Författare :Junko Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Isolated regional perfusion; ILP; IHP; Melphalan; Immunogenic cell death; T cells; Monocytes; ISG;

    Sammanfattning : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. LÄS MER

  5. 4. Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer

    Författare :Elin Edsbäcker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, these features are unique to each individual tumor and therefore a personalized treatment regimen needs to be composed for each patient. LÄS MER

  7. 5. Interfering with interferons : interplay between SARS-CoV-2 and interferon response

    Författare :Xi Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic, which has been an ongoing global health crisis. At the beginning of the pandemic, all the efforts were directed toward understanding the pathogenesis of the virus. LÄS MER