Sökning: "complex disease"

Visar resultat 16 - 20 av 1465 avhandlingar innehållade orden complex disease.

1. 16. Comparative sequencing of candidate genes in complex disease

   Författare :Shane McCarthy; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA; Sequencing; Complex Disease; Candidate Gene;

   Sammanfattning : Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association studies are increasingly viable alternatives to linkage approaches in locating disease genes. LÄS MER

3. 17. The Hit-IT project : The development and evaluation of an internet-based complex intervention for primary healthcare patients with cardiovascular disease and insomnia

   Författare :Sandra Öberg; Anders Broström; Linda Johansson; Jonas Sandberg; Mattias Georgsson; Staffan Karlsson; Jönköping University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular disease; insomnia; cognitive behavioral therapy; internet-based; utility; effect; patient experience; complex intervention;

   Sammanfattning : There is a need to explore insomnia among patients with cardiovascular disease (CVD), since they have increased risk for disease deterioration, poor quality of life and a shorter lifetime expectancy. Cognitive behavioral therapy (CBT) is the main recommended insomnia treatment, although it is a rare treatment choice in the healthcare due to lack of certified CBT therapists. LÄS MER

4. 18. Is it the gluten-free diet that matters the most? : Food, gender and celiac disease

   Författare :Ethel Kautto; Agneta Hörnell; Lena Aléx; Cecilia Olsson; Christina Berg; Umeå universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; gluten-free diet; gender; dietary assessment; adolescents; qualitative interviews; Kostvetenskap; Food and Nutrition;

   Sammanfattning : Background: The only treatment for celiac disease consists of excluding gluten. Gluten is a protein complex found in wheat, rye, and barley, which are cereals commonly used in bread, pasta, pizza, etc. LÄS MER

5. 19. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

   Författare :Michael Jewett; Translationell Neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

   Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

7. 20. Genetic Studies of Immunological Diseases in Dogs and Humans

   Författare :Matteo Bianchi; Gerli Rosengren Pielberg; Marta Alarcón-Riquelme; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complex disease; immunogenetics; autoimmunity; GWAS; NGS; canine model; dog; hypothyroidism; Addison s disease; IFNA; BACH2; Medical Genetics; Medicinsk genetik;

   Sammanfattning : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). LÄS MER