Sökning: "canine model"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden canine model.

  1. 1. Immunological Studies using Human and Canine Model Disorders

    Författare :Kerstin M. Ahlgren; Anna Lobell; Olle Kämpe; Kerstin Lindblad-Toh; Roland Jonsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; T cell; T helper cell; B cell; Autoantibodies; Interferon; Interleukin; Dogs; APS-1; Candida albicans; fungus; Immunologi; Immunology; Medicin; Medicine;

    Sammanfattning : The studies presented in this thesis focus on human and canine models for autoimmune disease, with the main aim to gain new knowledge about disease mechanisms and to further evaluate the dog as a model for autoimmune disease. Autoimmune Polyendocrine Syndrome type 1 (APS-1) is a hereditary human multiorgan disease caused by mutations in the autoimmune regulator (AIRE) gene. LÄS MER

  3. 2. Genetic Studies of Immunological Diseases in Dogs and Humans

    Författare :Matteo Bianchi; Gerli Rosengren Pielberg; Marta Alarcón-Riquelme; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complex disease; immunogenetics; autoimmunity; GWAS; NGS; canine model; dog; hypothyroidism; Addison s disease; IFNA; BACH2; Medical Genetics; Medicinsk genetik;

    Sammanfattning : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). LÄS MER

  4. 3. Uncovering a Novel Pathway for Autoinflammation : With a Little Help from a Wrinkled Friend

    Författare :Mia Olsson; Kerstin Lindblad-Toh; Gerli Pielberg; Göran Andersson; Leif Andersson; Rikard Holmdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoinflammation; hyaluronic acid; amyloidosis; canine model; genetic association; Molekylär genetik; Molecular Genetics;

    Sammanfattning : A major challenge in medical genetics is to identify the mutations underlying heritable diseases. Dogs are excellent genetic models in the search for causative mutations, as they constitute a large library of naturally occurring heritable diseases many of which are analogous to those suffered by man. LÄS MER

  5. 4. Genetic Studies in Dogs Implicate Novel Genes Involved in Atopic Dermatitis and IgA Deficiency

    Författare :Katarina Tengvall; Kerstin Lindblad-Toh; Göran Andersson; Åke Hedhammar; Gerli Rosengren Pielberg; Ingrid Skelton Kockum; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; canine model; genetic association; immunogenetics; atopic dermatitis; IgA deficiency; Molekylär genetik; Molecular Genetics;

    Sammanfattning : This thesis presents genetic studies of atopic dermatitis (AD) and IgA deficiency in dogs.AD is a chronic inflammatory and pruritic skin disorder caused by allergic reactions against environmental allergens. Both genetic and environmental factors are involved in the development of Canine AD (CAD) and human AD. LÄS MER

  7. 5. Canine inherited retinal degenerations: a model for visual impairment in humans

    Författare :Suvi Mäkeläinen; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inherited retinal degenerations (IRDs) form a clinically and genetically heterogeneous group of diseases, leading to visual impairment or blindness in both humans and dogs. The prevalence of IRDs is estimated at 1 in 2,000 in humans. LÄS MER