Sökning: "Translationell Neurogenetik"

Hittade 3 avhandlingar innehållade orden Translationell Neurogenetik.

  1. 1. The etiology of Parkinson's disease. Genetic and non-genetic risk factors for a multifactorial disease

    Författare :Kajsa Brolin; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Genetics; Environmental factors; Genome wide association study; Risk factors;

    Sammanfattning : .... LÄS MER

  3. 2. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Författare :Michael Jewett; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

  4. 3. Immunogenetics of Parkinson's disease: Translational studies from rodents to humans

    Författare :Itzia Jimenez; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetics; inflammation; α-synuclein; dopaminergic neurons; MHCII; Mhc2ta; Vra4; PFFs; microglia;

    Sammanfattning : Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. LÄS MER