Sökning: "IFNA"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet IFNA.

  1. 1. Genetic Studies of Immunological Diseases in Dogs and Humans

    Författare :Matteo Bianchi; Gerli Rosengren Pielberg; Marta Alarcón-Riquelme; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complex disease; immunogenetics; autoimmunity; GWAS; NGS; canine model; dog; hypothyroidism; Addison s disease; IFNA; BACH2; Medical Genetics; Medicinsk genetik;

    Sammanfattning : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). LÄS MER

  3. 2. Monoclonal antibodies to human interferon-α and interferon-γ : Characterization and application with focus on interferon-γ as a T cell cytokine

    Författare :Gudrun Andersson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : The major functions of the immune system are to combat infections and to control that normal auto-immunity does not turn into auto-aggression. Antibodies, together with T cell receptors and MHC molecules, dictates the immunological specificity. LÄS MER

  4. 3. Cell cycle regulatory genes in human astrocytic tumors

    Författare :Koichi Ichimura; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a genetic disorder of somatic cells. Neoplastic transformation and malignant progression may be a consequence of accumulated multiple genetic changes in a cell. Astrocytic gliomas are the commonest brain tumors in humans. LÄS MER

  5. 4. Multiple Sclerosis: Studies of the Interferon system and search for infectious agents

    Författare :My Bergkvist; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; Axon and myelin damage; IgG; Virus; Interferon; Multiple Sclerosis; Genetic linkage;

    Sammanfattning : Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. LÄS MER

  7. 5. Interferon-alpha based treatment of metastatic malignant melanoma : Effect of immune parameters of importance for monitoring immunotherapy

    Författare :Annika Håkansson; Sten Nilsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Cutaneous malignant melanoma is a rapidly increasing disease. Most patients are cured by surgical excision of their primary tumour, but for patients with metastatic disease the prognosis is still very poor despite various attempts with chemotherapeutic agents, and during the last decade with immunotherapy, using several different biological agents alone or in combination. LÄS MER