Sökning: "co-expression"

Visar resultat 21 - 25 av 100 avhandlingar innehållade ordet co-expression.

  1. 21. Sequence based analysis of neurodevelopmental disorders

    Författare :Jonatan Halvardson; Lars Feuk; Alexandre Reymond; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical Genetics; Medicinsk genetik;

    Sammanfattning : In this thesis the main focus is the use of methods and applications of next generation sequencing in order to study three of the most common neurodevelopmental disorders: intellectual disability, epilepsy and schizophrenia. A large fraction of the genes in our genome produce several distinct transcript isoforms through the process of splicing and there is an increasing amount of evidence pinpointing mutations affecting splicing as a mechanism of disease. LÄS MER

  3. 22. The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome

    Författare :Karoline Berger; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; biomarker; cancer stem cells; microenvironment; progranulin; sortilin; interleukin-6; targeted therapy; prognostic;

    Sammanfattning : Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting treatment-resistant cancer stem cells. LÄS MER

  4. 23. A study of ethylene production via the 2-oxoglutarate dependent pathway in S. cerevisiae

    Författare :Nina Johansson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ethylene forming enzyme; Ethylene; respiration rate; Saccharomyces cerevisiae; cultivation; production; nitrogen metabolism; 2-oxoglutarate; enzyme engineering; metabolic modeling;

    Sammanfattning : The detrimental effect of the petroleum industry on the environment combined with the threat of peak oil has driven the exploration for alternative strategies to produce traditional petrochemicals. Biotechnological production could be an alternative, using microorganisms to convert renewable feedstocks into desired products. LÄS MER

  5. 24. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition

    Författare :Maria Sandström; Roger Henriksson; Mikael Johansson; Anja Smits; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; angiogenesis; VEGF; tyrosinekinaseinhibitor; ZD6474; plasminogenactivator; tPA; uPA; proteomics; Oncology; Onkologi;

    Sammanfattning : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. LÄS MER

  7. 25. Haptoglobin: Biosynthesis and Evolution

    Författare :Krzysztof B. Wicher; Erik Fries; John W. M. Creemers; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; haptoglobin; cleavage; C1r-LP; evolution; vertebrate; endoplasmic; Golgi; complement; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). LÄS MER