Sökning: "clonidine"

Visar resultat 11 - 15 av 19 avhandlingar innehållade ordet clonidine.

1. 11. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

   Författare :Wei Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

   Sammanfattning : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. LÄS MER

3. 12. Short- and long-term cardiovascular and behavioural effects of oxytocin : mechanisms involved and influence of female steroid hormones

   Författare :Maria Petersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :oxytocin; nociceptive thresholds; naloxone; blood pressure; heart rate; spontaneous motor activity; oestrous cycle; ovariectomy; oestradiol; progesterone; weight gain; clonidine; locus coeruleus; alpha 2-adrenoreceptor; cholecystokinin; insulin; gastrin; corticosterone; ACTH; rat;

   Sammanfattning : The aim of the present thesis was to investigate short- and long-term cardiovascular and behavioural effects of oxytocin. In addition, the influence of female steroid hormones as well as possible mechanisms behind the oxytocin induced effects were investigated. LÄS MER

4. 13. Advances in spinal cord stimulation : enhancement of efficacy, improved surgical technique and a new indication

   Författare :Göran Lind; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :spinal cord stimulation;

   Sammanfattning : Introduction and aim: Spinal cord stimulation (SCS) has been used for treatment of otherwise therapy-resistant chronic neuropathic pain for about four decades. However, 30-40 % of the patients do not benefit from SCS, despite careful case selection and technical advances. LÄS MER

5. 14. Experimental nerve injury : induced pain : mechanisms and modulation

   Författare :Johan Wallin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chronic nerve injury-induced pain presents a therapeutic challenge since such pain is often resistant to conventional analgesic drugs including opioids. Better knowledge of the pathophysiological mechanisms underlying nerve injuryinduced pain is necessary to develop new and more efficacious therapies. LÄS MER

7. 15. Prevention of beta-cell dysfunction via targeting novel GPCRs in pancreatic islets

   Författare :Rajesh Kumar; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type II Diabetes; GPCR; Pancreatic islets; Estrogen; Alpha-1 antitrypsin.;

   Sammanfattning : The primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. LÄS MER