Sökning: "selective opioid agonists"

Hittade 4 avhandlingar innehållade orden selective opioid agonists.

  1. 1. Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT7 Ligands and Salvinorins

    Författare :Pär Holmberg; Anders Karlén; Adolf Gogoll; Anette Johansson; Christer Sahlberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; serotonin system; opioid system; selective 5-HT7 agonist; 3-aminchromans; salvinorin A; selective kappa opioid receptor; mental disorders; consciousness; regioselective oxidation; enzymatic kinetic resolution; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. LÄS MER

  3. 2. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

    Författare :Wei Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

    Sammanfattning : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. LÄS MER

  4. 3. Treatment of pain behavior after spinal cord injury in rats with special emphasis on the role of adenosine receptors

    Författare :Margareta von Heijne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adenosine; adenosine receptors; allodynia; baclofen; central pain; clonidine; intrathecal; morphine; neuropathic pain; opioid; rat; R-phenylisopropyladenosine; spinal cord injury; tolerance;

    Sammanfattning : Central pain is a form of neuropathic pain occurring after injury or dysfunction in the central nervous system, including the spinal cord. Allodynia (pain to innocuous stimuli) to mechanical and cold stimulation is a common feature of central pain and it is often resistant to treatment. LÄS MER

  5. 4. Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin

    Författare :Stefan Grass; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endomorphin; flexor reflex; galanin; knock-out mice; neuropathic pain; nociceptin; orphanin FQ transgenic mice;

    Sammanfattning : Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, it would be impossible to turn ones focus away from even the most minor painful stimulus. LÄS MER