Sökning: "naloxone"

Visar resultat 1 - 5 av 31 avhandlingar innehållade ordet naloxone.

  1. 1. Neuroinflammation and pain

    Författare :Linda Block; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroinflammation; Pain; Persistant pain; Astrocytes; Morphine; Naloxone; Intrathecal administration;

    Sammanfattning : ABSTRACT Background: Persistent pain that remains long after the physiological trigger has been resolved is a disabling condition. A possible mechanism for the transition from acute physiological pain to persistent pain involves low-grade inflammation in the central nervous system, in which inflammatory-activated astrocytes play a significant role. LÄS MER

  3. 2. Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia : New role of heat shock protein, nitric oxide and carbon monoxide : an experimental study in rat using light and electron microscopy

    Författare :Hari Shanker Sharma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; blood-brain barrier; heat stress; hyperthermia; brain edema; serotonin; nitric oxide; carbon monoxide; heat shock protein; glial fibrillary acidic protein; myelin basic protein; opioids; histamine; catecholamines; naloxone; indomethacin; p-CPA; electron microscopy; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

    Sammanfattning : This thesis deals with the molecular mechanisms of hyperthermia induced brain damage in rats. The results clearly establish that hyperthermia caused by 4 h heat stress at 38° C is associated with a breakdown of the blood-brain barrier (BBB) permeability which seems to be instrumental in causing brain edema and cell injury. LÄS MER

  4. 3. Effects of TRH, naloxone and morphine on cerebral and some other peripheral blood flows : evidence for a physiological role of TRH in cardiovascular control

    Författare :Lars-Owe D. Koskinen; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Effective treatment in patients with opioid use disorder. Prevention of somatic disease, overdose morbidity and mortality in a high-risk population

    Författare :Katja Troberg; Lund Psykiatri; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Opioid use disorder; overdose education and naloxone distribution; take-home naloxone; opioid substitution treatment; somatic symptoms; unmet healthcare needs.; Opioid use disorder; overdose education and naloxone distribution; take-home naloxone; opioid substitution treatment; somatic symptoms; unmet healthcare needs.;

    Sammanfattning : .... LÄS MER

  7. 5. Short- and long-term cardiovascular and behavioural effects of oxytocin : mechanisms involved and influence of female steroid hormones

    Författare :Maria Petersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :oxytocin; nociceptive thresholds; naloxone; blood pressure; heart rate; spontaneous motor activity; oestrous cycle; ovariectomy; oestradiol; progesterone; weight gain; clonidine; locus coeruleus; alpha 2-adrenoreceptor; cholecystokinin; insulin; gastrin; corticosterone; ACTH; rat;

    Sammanfattning : The aim of the present thesis was to investigate short- and long-term cardiovascular and behavioural effects of oxytocin. In addition, the influence of female steroid hormones as well as possible mechanisms behind the oxytocin induced effects were investigated. LÄS MER