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Visar resultat 1 - 5 av 19 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Development and Applications of Molybdenum-Catalyzed Chemoselective Amide Reduction

    Författare :Tove Slagbrand; Hans Adolfsson; André Charette; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hydrosilylation; reduction; reductive functionalization; catalysis; amides; enamines; chemoselective; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis covers the development of catalytic methodologies for the mild and chemoselective hydrosilylation of amides. The first part describes the investigation of the Mo(CO)6-catalyzed reduction of carboxamides. LÄS MER

  3. 2. Development of advanced chemical biology tools for microbiome metabolism : Chemoselective probes for enhanced metabolomics analysis

    Författare :Weifeng Lin; Daniel Globisch; Frank Schroeder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemical biology; Chemoselective modification; Chemical metabolomics; Bioorganic; Microbiome metabolism; Kemi; Chemistry;

    Sammanfattning : The human microbiome has a profound impact on host physiology by generating highly reactive compounds that can contribute to the development of diseases. These microbial metabolites have a substantial potential that can serve as valuable indicators or biomarkers for different health conditions. LÄS MER

  4. 3. Oxidative Trifluoromethylation and other Functionalization Reactions of Alkenes and Alkynes

    Författare :Pär Janson; Kálmán Szabó; Antonio Togni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; transition metal; trifluoromethylation; catalysis; acetoxylation; difunctionalization; oxidation; mechanistic study; alkenes; alkynes; quinones; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis concerns the use of various potent oxidants in organic synthesis. The main focus is directed at selectively introducing trifluoromethyl groups into compounds containing double or triple bonds. All reactions proceed under mild conditions and can in most cases be performed on the bench-top. LÄS MER

  5. 4. Lipase chemoselectivity - kinetics and applications

    Författare :Cecilia Hedfors; Karl Hult; Mats Martinelle; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica lipase B; Rhizomucor miehei lipase; active site titration; kinetics; chemoselectivity; thiol; alcohol; thiol-functionalized polyesters; Biochemistry; Biokemi;

    Sammanfattning :   A chemoselective catalyst is preferred in a chemical reaction where protecting groups otherwise are needed. The two lipases Candida antarctica lipase B and Rhizomucor miehei lipase showed large chemoselectivity ratios, defined as (kcat/KM)OH / (kcat/KM)SH, in a transacylation reaction with ethyl octanoate as acyl donor and hexanol or hexanethiol as acyl acceptor (paper I). LÄS MER

  7. 5. Photochemical Ligation Techniques for Carbohydrate Biosensors and Protein Interaction Studies

    Författare :Oscar Norberg; Olof Ramström; Stéphane Vincent; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Biosensors; CuAAC; Photochemistry; Thiol-ene yne; Perfluorophenylazide PFPA ; Lectins; Molecular recognition; Quartz crystal microbalance QCM ; Surface plasmon resonance SPR ;

    Sammanfattning : This thesis concerns the development of surface ligation techniques for the preparation of carbohydrate biosensors. Several methodologies were developed based on efficient photochemical insertion reactions which quickly functionalize polymeric materials, with either carbohydrates or functional groups such as alkynes or alkenes. LÄS MER