Sökning: "mechanistic study"

Visar resultat 1 - 5 av 391 avhandlingar innehållade orden mechanistic study.

  1. 1. Cannabinoids as neuroprotective agents : a mechanistic study

    Författare :Olov Nilsson; Christopher Fowler; Edward Högestätt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid; neuroprotection; inflammation; cytokine; neutrophil; Pharmacology; Farmakologi;

    Sammanfattning : Glucose and oxygen supply to the brain is critical for its proper function and when it is restricted as during a stroke, neurons and glial cells quickly become necrotic leading to structural damage as well as functional impairment and even death. To date there are few effective therapies that inhibit the neurodegenerative process and improves the outcome for the affected individual. LÄS MER

  3. 2. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations

    Författare :Johanna M. Larsson; Kálmán J. Szabó; Dennis G. Hall; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; catalysis; Heck reaction; C-H functionalization; allylic substitution; silylation; borylation; trifluoromethylation; fluorination; mechanistic study; transition metal; alkene; allylic silane; allylic boronate; allylic fluoride; organisk kemi; Organic Chemistry;

    Sammanfattning : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. LÄS MER

  4. 3. Oxidative dissolution of doped UO2 and H2O2 reactivity towards oxide surfaces : A kinetic and mechanistic study

    Författare :Kristina Nilsson; Mats Jonsson; Mats Johansson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Oxidative dissolution; UO2; ADOPT; H2O2; Spent Nuclear Fuel.; Kemi; Chemistry;

    Sammanfattning : Oxidative dissolution of std. UO2 and UO2 doped with Cr2O3 and Al2O3, i.e. ADOPT, induced by H2O2 and γ radiation has been the main focus in this licentiate thesis. LÄS MER

  5. 4. Asymmetric transfer hydrogenation of ketones : Catalyst development and mechanistic investigation

    Författare :Katrin Ahlford; Hans Adolfsson; Martin Wills; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; reduction; amino acid; rhodium; mechanistic investigation; kinetic study; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : The development of ligands derived from natural amino acids for asymmetric transfer hydrogenation (ATH) of prochiral ketones is described herein. In the first part, reductions performed in alcoholic media are examined, where it is found that amino acid-derived hydroxamic acids and thioamides, respectively, are simple and versatile ligands that in combination with [RhCp*Cl2]2 efficiently catalyze this particular transformation. LÄS MER

  7. 5. The effect of solid state inclusions on the reactivity of UO2 : A kinetic and mechanistic study

    Författare :Martin Trummer; Mats Jonsson; Lara Duro; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear chemistry; Kärnkemi;

    Sammanfattning : The release of radionuclides is a key process in the safety assessment of a deep geological repository for spent nuclear fuel. A large fraction of the release is assumed to be a consequence of dissolution of the fuel matrix, UO2. In this doctoral thesis, the kinetics and the mechanisms behind oxidative U(IV) dissolution were studied. LÄS MER