Sökning: "cell experiments"

Visar resultat 11 - 15 av 1109 avhandlingar innehållade orden cell experiments.

  1. 11. Influence of neuromodulators and mechanical loading on pathological cell and tissue characteristics in tendinosis

    Författare :Gloria Fong; Patrik Danielson; Alex Scott; Ludvig Backman; Paul Ackermann; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P; acetylcholine; transforming growth factor; neuromodulators; mechanical loading; tendinosis; anatomi; Human Anatomy;

    Sammanfattning : Background: Tendinosis is a painful chronic, degenerative condition characterized by objective changes in the tissue structure of a tendon. Hallmark features in tendinosis tendons include increased number of cells (hypercellularity), extracellular matrix (ECM) degradation and disorganized collagen. LÄS MER

  3. 12. Defining the role of CD47 and SIRPα in murine B cell homeostasis

    Författare :Shrikant S Kolan; Per-Arne Oldenborg; Mikael Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; CD47; SIRPα; Follicular B cell; Marginal zone macrophages; immunologi; Immunology;

    Sammanfattning : B cell development is a highly organized process, which commences in the fetal liver during embryogenesis and in the bone marrow (BM) after birth. Surface IgM+ immature B cells emigrate from the BM via the blood stream to the spleen and finally differentiate into conventional mature follicular B (FoB) cells and marginal zone (MZ) B cells. LÄS MER

  4. 13. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

    Författare :Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. LÄS MER

  5. 14. Non-coding RNAs and Extracellular Vesicles in Cutaneous Squamous Cell Carcinoma

    Författare :Chen Li; Andor Pivarcsi; Gareth Inman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cutaneous squamous cell carcinoma; microRNA; long non-coding RNA; extracellular vesicle;

    Sammanfattning : Cutaneous squamous cell carcinoma (cSCC) ranks among the most widespread malignancies with metastatic potential. Investigating the molecular mechanism of tumorigenesis will enhance our understanding of cSCC. Aberrant expression of non-coding RNAs has been extensively reported in human cancers. LÄS MER

  7. 15. The cell biology and catalytic properties of the nutrient-induced signaling endoprotease Ssy5

    Författare :António Martins; Per O. Ljungdahl; Bruno André; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nutrient sensing; signal transduction; regulated proteolysis; endoprotease; serine protease; substrate specificity; subcellular fractionation; Saccharomyces cerevisiae; Cell Biology; cellbiologi;

    Sammanfattning : Cells continuously sense and respond to changes in the presence, quality and quantity of external and internal nutrients. Specific signaling proteases have been identified based on their roles in processing or destruction of distinct sets of downstream effector proteins in response to environmental cues. LÄS MER