Sökning: "long non-coding RNA"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden long non-coding RNA.

1. 1. Regulation of TGFβ signaling by long non-coding RNAs and ADP-ribosylation

   Författare :Panagiotis Papoutsoglou; Aristidis Moustakas; Carl-Henrik Heldin; Peter Zaphiropoulos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; signal transduction; long non-coding RNAs; ADP-ribosylation; transcriptional regulation; chromatin remodeling; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Transforming growth factor β (TGFβ) signaling pathways participate in embryonic development and tissue homeostasis and have a dual role in cancer. TGFβ acts as a tumor suppressor that promotes cell cycle arrest and apoptosis at initial stages of tumorigenesis. LÄS MER

3. 2. Non-coding RNAs and Extracellular Vesicles in Cutaneous Squamous Cell Carcinoma

   Författare :Chen Li; Andor Pivarcsi; Gareth Inman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cutaneous squamous cell carcinoma; microRNA; long non-coding RNA; extracellular vesicle;

   Sammanfattning : Cutaneous squamous cell carcinoma (cSCC) ranks among the most widespread malignancies with metastatic potential. Investigating the molecular mechanism of tumorigenesis will enhance our understanding of cSCC. Aberrant expression of non-coding RNAs has been extensively reported in human cancers. LÄS MER

4. 3. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

   Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

5. 4. Characterization of non-coding RNAs in cancer

   Författare :Per Johnsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed underappreciated roles of non-protein coding RNAs (ncRNAs). LÄS MER

7. 5. Functional analysis of long non-coding RNAs in cancer

   Författare :Linda Vidarsdottir; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives and prompted scientists to further look into the involvement of noncoding RNAs (ncRNAs) in development and disease. LÄS MER