Sökning: "SIRPα"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet SIRPα.

  1. 1. Studies of SIRPα-mediated regulation of neutrophil functions

    Författare :Åsa Stenberg; Janove Sehlin; Karl-Eric Magnusson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; SIRPα; inflammation; adhesion; chemotaxis; apoptosis;

    Sammanfattning : Neutrophil granulocytes constitute the front line of defense in the innate immune response to invading microorganisms, but can also contribute to development of inflammatory disease and tissue destruction following e.g. myocardial infarction or stroke. LÄS MER

  3. 2. Defining the role of CD47 and SIRPα in murine B cell homeostasis

    Författare :Shrikant S Kolan; Per-Arne Oldenborg; Mikael Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; CD47; SIRPα; Follicular B cell; Marginal zone macrophages; immunologi; Immunology;

    Sammanfattning : B cell development is a highly organized process, which commences in the fetal liver during embryogenesis and in the bone marrow (BM) after birth. Surface IgM+ immature B cells emigrate from the BM via the blood stream to the spleen and finally differentiate into conventional mature follicular B (FoB) cells and marginal zone (MZ) B cells. LÄS MER

  4. 3. Role of the CD47/SIRPα-interaction in regulation of macrophage phagocytosis

    Författare :Mattias Olsson; Per-Arne Oldenborg; Hans Tapper; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; immunology; cell biology; Histology; Histologi;

    Sammanfattning : CD47 is a cell surface glycoprotein that is expressed by virtually all cells in the body. Binding of CD47 to the macrophage receptor Signal Regulatory Protein alpha (SIRPα) yields an inhibitory signal that counteracts phagocytosis. LÄS MER

  5. 4. CD47–SIRPα : an interaction of importance for bone cell differentiation

    Författare :Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

    Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER

  7. 5. Interaction between nerve fiber formation and astrocytes

    Författare :Sanazalsadat Hashemian; Ingrid Strömberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; spinal cord; CSPG; CD47;

    Sammanfattning : Parkinson’s disease, the second most common neurodegenerative disorder,is characterized by loss of nigrostriatal dopaminergic neurons. To date,there is no defined cause and cure for the disease. An ideal treatmentstrategy is to replace the lost neurons by transplanting fetal dopaminergicneurons to the brain of parkinsonian patients. LÄS MER