Sökning: "autoinflammation"

Hittade 4 avhandlingar innehållade ordet autoinflammation.

  1. 1. Uncovering a Novel Pathway for Autoinflammation : With a Little Help from a Wrinkled Friend

    Författare :Mia Olsson; Kerstin Lindblad-Toh; Gerli Pielberg; Göran Andersson; Leif Andersson; Rikard Holmdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoinflammation; hyaluronic acid; amyloidosis; canine model; genetic association; Molekylär genetik; Molecular Genetics;

    Sammanfattning : A major challenge in medical genetics is to identify the mutations underlying heritable diseases. Dogs are excellent genetic models in the search for causative mutations, as they constitute a large library of naturally occurring heritable diseases many of which are analogous to those suffered by man. LÄS MER

  3. 2. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

    Författare :Deepti Verma; Peter Söderkvist; Ulf Andersson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; Medical genetics; Medicinsk genetik;

    Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER

  4. 3. Pediatric Autoinflammatory Diseases: Conceptual, Clinical, and Mechanistic Dimensions

    Författare :Per Wekell; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; child; fever; inflammation; cytokines; familial Mediterranean; neutrophils;

    Sammanfattning : This thesis focuses on three paediatric autoinflammatory diseases in Sweden today; familial Mediterranean fever (FMF), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO). In addition to describing autoinflammation with reference to these diseases, the thesis explores the concept of autoinflammatory disease by examining four existing definitions. LÄS MER

  5. 4. Regulation of cytotoxic lymphocyte effector functions

    Författare :Giovanna Perinetti Casoni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Studies of patients with inborn errors of immunity provide an important opportunity to understand the human immune system in a natural context. The articles in this thesis are a compilation of such investigations. LÄS MER