Sökning: "breast cancer induction"

Visar resultat 21 - 25 av 52 avhandlingar innehållade orden breast cancer induction.

  1. 21. Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy

    Författare :Xiaolei Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more heterogenous and aggressive, which results in tumor resistance to anti-cancer therapies and therefore can be lethal. LÄS MER

  3. 22. Apoptosis induced by a human milk protein complex. Cellular and structural studies in tumour cells and bacteria

    Författare :Anders Håkansson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; nuclear uptake; caspases; mitochondria; S. pneumoniae; alpha-lactalbumin; milk; breast-feeding; Apoptosis; tumour cells; transplantation; Immunologi; serologi;

    Sammanfattning : Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. LÄS MER

  4. 23. Molecular characterization of estrogen receptor beta variants : cancer cell proliferation and invasion

    Författare :Li Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen plays crucial roles in the pathogenesis of breast cancer. Most of the known effects of estrogen signaling are mediated by estrogen receptors (ERs), ERα and ERβ. ERα is explored for breast cancer molecular classification and is a target of endocrine therapy. LÄS MER

  5. 24. Towards transcriptome-wide studies of mRNA translation in tissues from cancer patients

    Författare :Shuo Liang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene expression consists of multiple strictly regulated steps, including transcription, RNA modification, splicing, messenger RNA (mRNA) transport, mRNA degradation, mRNA translation and protein degradation. mRNA translation, the most energy consuming step, plays a critical role in gene expression via global and selective control of protein synthesis. LÄS MER

  7. 25. From ancient herbs to modern drugs : In search of alternatives for cancer therapy

    Författare :Wendy Soria Sotillo; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. LÄS MER