Sökning: "breast cancer induction"

Visar resultat 16 - 20 av 52 avhandlingar innehållade orden breast cancer induction.

  1. 16. Molecular and therapeutic aspects of breast cancer stem cells

    Författare :Ran Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer stem cells (BCSCs) are defined as a minor cellular component in the solid tumor, displaying mammary stem cell properties by expressing embryonic stem cell genes. They are usually undergoing self-. LÄS MER

  3. 17. Hormonal regulation of HES-1 in breast cancer cells

    Författare :Patrick Müller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis and hematopoiesis. HES-1 has several well conserved domains, from Drosophila to mammals, and is expressed in a variety of tissues, in both embryos and adults. LÄS MER

  4. 18. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors

    Författare :Joel Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. LÄS MER

  5. 19. Molecular mechanism of cell regulatory properties of vitamin D analogues in human cancer cell lines

    Författare :Carina Danielsson; Uppsala universitet; []
    Nyckelord :Medical sciences; vitamin D analogues; retinoids; cancer cell lines; promoter selectivity; cellregulatory properties; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Sammanfattning : The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is a potent modulator of the induction of differentiation and inhibition of cell growth in both malignant and normal cells. Vitamin D and its analogues exert their effects through a transcription factor, the nuclear vitamin D receptor (VDR). LÄS MER

  7. 20. Autophagy and VPS34 as targets in anti-cancer therapy

    Författare :Yasmin Désirée Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autophagy (Greek for self-eating) is a cellular pathway that breaks down cytoplasmic components to fuel metabolism. In this way, autophagy maintains cellular homeostasis and sustains survival during stress conditions. In cancer, autophagy is often dysregulated and has been described to contribute to malignancy and therapy resistance. LÄS MER