Sökning: "bFGF"

Visar resultat 6 - 10 av 39 avhandlingar innehållade ordet bFGF.

1. 6. Posterior capsule opacification : An experimental study in vitro and in vivo

   Författare :Niklas Wallentin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Posterior capsule opacification PCO ; after-cataract; lens epithelial cell; proliferation; aqueous humor AqH ; inflammation; growth factors; basic fibroblast growth factor bFGF ; transforming growth factor-β TGF-β ; extracapsular cataract extraction; corneal incision; rabbit; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

   Sammanfattning : The clinical and economic significance of posterior capsule opacification (PCO) makes it an important public health problem. A better understanding of the pathogenesis in order to reduce/prevent PCO is needed. For this purpose an experimental model in the rabbit was used and further developed in thisthesis. LÄS MER

3. 7. Positive and negative angiogenic factors in patients with malignant disease

   Författare :Christina Linder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :angiogenesis; neovascularization; microvessel density; VEGF; bFGF; stromelysin-3;

   Sammanfattning : In this thesis, the levels of positive and negative angiogenic factors were studied in tissue, serum and urine from patients with malignant disease. The angiogenic factors VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) were studied in breast carcinomas. LÄS MER

4. 8. Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods

   Författare :Xiaojin Hao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Angiogenesis; arteriogenesis; apoptosis; myocardial infarction; VEGF-A165; bFGF; PDGF-BB; adenovirus; plasmid; alginate;

   Sammanfattning : Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the optimal application of growth factors and delivery method requires further exploration. LÄS MER

5. 9. Gluco- and mineralocorticoid receptor regulation of regional brain neurotrophism

   Författare :Anita Christiane Hansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neurotrophins; BDNF; NT-3; bFGF; FGF receptor; immediate early genes; c-fos; antisense oligodeoxynucleotides; adrenalectomy; stress; glucocorticoids; mineralocorticoids; glucocorticoid receptor; mineralocorticoid; receptor in situ hybridization.;

   Sammanfattning : Gluco- and mineralocorticoid hormones exert powerful actions on brain function and are important in the mediation of the stress response and the survival of hippocampal neurons. The aim of this thesis was to study the influence of glucocorticoid (GR)/mineralocorticoid receptor (MR) actions on brain neurotrophism including analyses of immediate early genes (IEGs) and of feedback responses on GR and/or MR. LÄS MER

7. 10. Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate

   Författare :Nora Kerekes; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acute and long-term DRG cultures; aFGF; BDNF; bFGF; bradykinin; excitability; galanin; glutamate; leukemia inhibitory factor; neuropeptide Y; : NGF; regeneration; whole cell patch clamp.;

   Sammanfattning : Galanin (Gal) and neuropeptide Y (NPY) are two peptides, which are strongly up- regulated in a population of dorsal root ganglion (DRG) neurons after peripheral nerve injury (axotomy). Both peptides may be involved in the control of pain sensation, especially after nerve injury (neuropathic pain). LÄS MER