Sökning: "Neurotrophins"

Visar resultat 1 - 5 av 56 avhandlingar innehållade ordet Neurotrophins.

  1. 1. Neuropeptides and neurotrophins in arthritis : studies on the human and mouse knee joint

    Författare :Ola Grimsholm; Sture Forsgren; Solbritt Rantapää-Dahlqvist; Elvar Theodorsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropeptides; neurotrophins; bombesin gastrin-releasing peptide; substance P; brain-derived neurotrophic factor; synovial tissue; knee joint; rheumatoid arthritis; Anatomy; Anatomi;

    Sammanfattning : Neuropeptides, such as substance P (SP) and bombesin/gastrin-releasing peptide (BN/GRP), and neurotrophins are involved in neuro-immunomodulatory processes and have marked trophic, growth-promoting and inflammation-modulating properties. The impact of these modulators in rheumatoid arthritis (RA) is, however, unclear. LÄS MER

  3. 2. TNF-α and neurotrophins in Achilles tendinosis

    Författare :Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Sammanfattning : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. LÄS MER

  4. 3. Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression

    Författare :Anders Edsjö; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; oncology; cancerology; Cytology; N-myc.; trkC; trkB; trkA; neurotrophins; Neuroblastoma; sympathetic nervous system;

    Sammanfattning : Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. LÄS MER

  5. 4. Neurogenesis and gliogenesis after focal brain ischemia. Modulation by enriched environment and exercise

    Författare :Mila Komitova; Göteborgs universitet; []
    Nyckelord :astrocyte; hippocampus; neural progenitor cells; neural stem cells; neurogenesis; neurotrophins; rat; regeneration; rehabilitation; stroke;

    Sammanfattning : New neurons are formed from dividing neural stem cells in restricted areas in the adult mammalian brain: the dentate gyrus of the hippocampal formation (DG) and the forebrain subventricular zone (SVZ). New glia also form constitutively and seem to be important for neuronal function. LÄS MER

  7. 5. Cellular and molecular mechanisms of ischemic brain damage in hyperglycemic rats

    Författare :Hiroyuki Uchino; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Reperfusion injury; Mitochondria; Permeability transition; Cyclosporin A; Neurotrophins; Seizures; Brain damage; Acidosis; Hypercapnia; Ischemia; Hyperglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The present study is centered on mechanisms of ischemic brain damage in hyperglycemic animals, and in those in which exaggerated intraischemic acidosis was induced by superimposed hypercapnia in normoglycemic animals. The initial experiments were focussed on the pathophysiology of postischemic seizures. LÄS MER