Sökning: "bFGF"

Visar resultat 21 - 25 av 39 avhandlingar innehållade ordet bFGF.

  1. 21. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis

    Författare :Tove Sandberg; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics; endothelial cell migration; angiogenesis; uPA:PAI-1 complex; uPAR; TGF-beta; PAI-1; EGF; uPA; Growth factor; gynaecology; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

    Sammanfattning : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. LÄS MER

  3. 22. Stem cell transplantation in multiple myeloma : clinical aspects and experimental gene transfer studies

    Författare :Bo Björkstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :multiple myeloma; bone marrow transplantation; allogeneic; autologous; prognostic factors; hemato-poietic stem eells; gene therapy; gene transfer; retrovirus; basic fibroblast growth factor;

    Sammanfattning : Multiple myeloma (MM) is a hematological malignant disease considered essentially incurable despite its sensitivity to cytotoxic chemotherapeutic drugs and radiation. High-dose chemo/radiotherapy with allogeneic- or autologous hematopoietic stem cell transplantation (tx) can induce a disease-free state and may prolong survival and offer an improved quality of life to MM patients. LÄS MER

  4. 23. Studies on pain-related messengers and receptors in dorsal root ganglia and spinal cord

    Författare :Malin Rydh-Rinder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain is the most common reason why people seek medical advice. A large group of patients suffering from so-called neuropathic pain, due to injury to the nervous system itself, is often not helped by the currently available therapies. Classical analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, may have severe side effects. LÄS MER

  5. 24. Matrix metalloproteases and cell motility in malignant mesothelioma

    Författare :Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

    Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER

  7. 25. Platelet Activation and Inhibition in Connection with Vascular Stents

    Författare :Kjeld Christensen; Rolf Larsson; Sten Husted; Uppsala universitet; []
    Nyckelord :Medicine; platelets; inhibition; activation; stents; ACS; Medicin;

    Sammanfattning : This thesis describes the Chandler loop, which makes it possible to conduct studies in vitro of molecular and cellular interactions between whole blood and stents. It was possible to monitor activation and inhibition of the cascades systems, leukocytes and platelets by combining different platelet inhibitors and heparin coating of stents. LÄS MER