Sökning: "arteriogenesis"

Hittade 4 avhandlingar innehållade ordet arteriogenesis.

1. 1. Collateral development in limb ischemia : aspects of endogenous and stimulated arteriogenesis

   Författare :Ulrika Palmer Kazen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :PAD; CLI; intermittent claudication; VEGF; FGF-2; angiogenesis; arteriogenesis; gene therapy; adenovirus; AdFGF-4; rat hindlimb ischemia model; randomized clinical trial;

   Sammanfattning : Peripheral arterial disease (PAD) is common among elderly and affects about 20% of the population above the age of 60 years. PAD is a strong marker for future cardiovascular events and increased mortality due to widespread atherosclerotic lesions in the coronary and cerebral arteries. LÄS MER

3. 2. Therapeutic myocardial angiogenesis and its pharmacological modulation

   Författare :Anwar J Siddiqui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Angiogenesis; arteriogenesis; ischemic heart; vascular endothelial growth factor; angiopoietin and receptor;

   Sammanfattning : Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of combined angiogenic factors. LÄS MER

4. 3. Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods

   Författare :Xiaojin Hao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Angiogenesis; arteriogenesis; apoptosis; myocardial infarction; VEGF-A165; bFGF; PDGF-BB; adenovirus; plasmid; alginate;

   Sammanfattning : Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the optimal application of growth factors and delivery method requires further exploration. LÄS MER

5. 4. Myocardial angiogenesis : aspects on endogenous determinants and effects of stimulation

   Författare :Agneta Månsson Broberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myocardial infarction; ischemia; angiogenesis; VEGF- A165; gene therapy; adenovirus; plasmid; ephrinB2; darbepoietin-alpha; apoptosis; estrogen receptors;

   Sammanfattning : Background: Therapeutic angiogenesis using i.e. VEGF and FGF have shown beneficial effects, however, delivery routes and other modulating agents have not been thoroughly investigated. In this study the efficacy of adenovirus gene transfer was compared to plasmid gene transfer. LÄS MER