Sökning: "amyloid beta"

Visar resultat 21 - 25 av 171 avhandlingar innehållade orden amyloid beta.

1. 21. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

   Författare :Annika Olsson; Göteborgs universitet; []
   Nyckelord :Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

   Sammanfattning : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). LÄS MER

3. 22. Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease

   Författare :Wojciech Michno; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; beta-amyloid; electron microscopy; imaging mass spectrometry; lipids; luminescent conjugated oligothiophenes; matrix-assisted laser desorption ionization mass spectrometry MALDI-MS ; molecular imaging; nanoscale secondary ion mass spectrometry NanoSIMS ; neurodegeneration; peptides;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired amyloid-positive (CU-AP) individuals, but these Aβ plaques are primarily diffuse in structure. LÄS MER

4. 23. Engineering of Affibody molecules targeting the Alzheimer’s-related amyloid β peptide

   Författare :Hanna Lindberg; Stefan Ståhl; John Löfblom; Caroline Ekblad; Sara Snogerup Linse; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; Alzheimer’s disease; AD; amyloid beta; Aß; combinatorial protein engineering; staphylococcal surface display; Bioteknologi; Biotechnology;

   Sammanfattning : .... LÄS MER

5. 24. Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP)

   Författare :Ella Karlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; alpha cell; amylin; beta cell; chromogranin; growth; IAPP; insulin; islet amyloid polypeptide; leptin; NOD mice; pancreastatin; pancreatic islet; proliferation; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986. The aim of the present work was to determine the role of the beta cell hormone, IAPP, in normal pancreatic islet physiology and during early disturbances of islet function. LÄS MER

7. 25. The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance

   Författare :Carl-Henrik Andersson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microglia; neuroinflammation; amyloid-beta; Alzheimer s disease; genetic association; biomarker; cerebrospinal fluid; zebrafish; clearance; in vivo imaging;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration leading to memory loss. LÄS MER