Sökning: "VSMC"

Visar resultat 11 - 15 av 27 avhandlingar innehållade ordet VSMC.

  1. 11. The role of the G protein-coupled receptor ChemR23 in cardiovascular inflammation

    Författare :Gonzalo Artiach Castañón; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular inflammation is a biological process characterized by the immune cell response to harmful stimuli within the cardiovascular system, wherein homeostasis is reestablished by neutralizing the insult and promoting the repair of the damaged tissue. However, a failure in the resolution of inflammation can lead to a maladaptive inflammatory response, contributing to the development of cardiovascular diseases such as aortic valve stenosis (AVS) and atherosclerosis, as well as vascular complications such as intimal hyperplasia. LÄS MER

  3. 12. Molecular mechanisms of cardiovascular calcification

    Författare :Miguel Carracedo Ortiz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial stiffness, which may lead to poor cardiac perfusion, systolic hypertension and heart failure. LÄS MER

  4. 13. Neuropeptide Y - aspects of vasomotorresponses and receptor characterization

    Författare :Torun Nilsson-Bergdahl; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vasoconstriction; RT-PCR; receptor characterization; potentiation; NPY Y1 receptor; NPY; mitogenesis; hypertension; human arteries; forearm blood flow; cell culture; antisense oligodeoxynucleotides; BIBP3226; vasodilatation.; Physiology; Fysiologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Abstract The aims of the present thesis were to examine neuropeptide Y (NPY) responses in different human and guinea pig vascular beds and in cultured human vascular smooth muscle cells (VSMC) and to characterize, with different NPY agonists and the specific NPY Y1 receptor antagonist (BIBP3226), the NPY receptors involved. NPY-induced strong and potent contractions in human cerebral and subcutaneous arteries and in guinea pig basilar arteries. LÄS MER

  5. 14. Novel Agonists and Antagonists of Platelet Receptors

    Författare :Carl Högberg; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Platelets; P2Y12; SUCNR1; FPP; hypothermia;

    Sammanfattning : Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. LÄS MER

  7. 15. Interplay between inflammation and calcification in cardiovascular diseases

    Författare :Nikolaos-Taxiarchis Skenteris; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular calcification has been linked to all-cause mortality and is a broadly adopted predictor of cardiovascular (CV) events. Rather than a mere by-product of the changing disease environment, calcification impacts actively the disease progression and pathogenesis as it predominates both in early- and late-stages, through mediating tissue biomechanical destabilisation and directly impacting tissue inflammation. LÄS MER