Sökning: "VSMC"
Visar resultat 21 - 25 av 27 avhandlingar innehållade ordet VSMC.
21. Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL
Sammanfattning : The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the NOTCH3 receptor, which is highly expressed in vascular smooth muscle cells (VSMC), are associated with various diseases, including developmental disorders, several forms of cancer, and vascular dementia. LÄS MER
22. Innate immunity in atherosclerosis : the role of pattern recognition receptors
Sammanfattning : The pathogenesis of atherosclerosis is greatly influenced by the activities of both innate and adaptive immunity. Danger signals such as cholesterol crystals, oxidized LDL, and modified phospholipids may trigger sterile inflammation in atherosclerosis. LÄS MER
23. Innate immune mechanisms of atherosclerosis
Sammanfattning : Atherosclerosis is a multi-factorial immune mediated disease in arterial wall characterized by lipid driven inflammation through activation of the immune system. Chronic vascular inflammation is an important component that modulates atherosclerosis evolution and its complications. LÄS MER
24. Challenging the mystique Connection. Deciphering cell-matrix interactions role in atherosclerosis and restenosis
Sammanfattning : Atherosclerosis is the underlying cause for myocardal infarction, stroke and peripheral arterial disease, collectively referred to as cardiovascular diseases. These represent the major cause of death globally. LÄS MER
25. The role of PDGF-B in brain blood vessels
Sammanfattning : The development of blood vessels is dependent on several molecular cues to form properly. A functional PDGF-B/PDGFR-b signaling is paramount for the investment of mural cells, that provide with support, to the developing vasculature. LÄS MER