Sökning: "P2Y12"

Visar resultat 1 - 5 av 29 avhandlingar innehållade ordet P2Y12.

1. 1. Platelet Inhibition in Coronary Artery Disease – Mechanisms and Clinical Importance : Studies with Focus on P2Y12 Inhibition

   Författare :Christoph Varenhorst; Stefan James; Agneta Siegbahn; Lars Wallentin; Steen Dalby Kristensen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary artery disease; myocardial infarction; acute coronary syndromes; stent thrombosis; P2Y12 inhibitors; thienopyridines; clopidogrel poor response; clopidogrel; prasugrel; Cardiology; Kardiologi; Kardiologi; Cardiology;

   Sammanfattning : Despite the currently recommended dual antiplatelet treatment (DAT) with aspirin and P2Y12 inhibition in patients with coronary artery disease (CAD) there is a risk of adverse clinical outcome. Pharmacodynamic (PD) poor response to clopidogrel occurs in ~ 30% of clopidogrel-treated patients and is associated with an increased risk of recurrent thrombotic events. LÄS MER

3. 2. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12

   Författare :Peter Bach; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mGluR5; P2Y12; gastroesophageal reflux disease GERD ; thrombosis; ethyl nicotinates; ureas; sulfonylureas; oxazoles; bioisosteres; regioselectivity; solvent effect.;

   Sammanfattning : The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was developed to investigate the structure-activity relationships (SAR) of a novel series of 2-alkynylpyridine derivatives as mGluR5 antagonists. LÄS MER

4. 3. Novel Agonists and Antagonists of Platelet Receptors

   Författare :Carl Högberg; Kardiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Platelets; P2Y12; SUCNR1; FPP; hypothermia;

   Sammanfattning : Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. LÄS MER

5. 4. Impact of chronic total occlusions, arterial access site, and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry

   Författare :Christian Dworeck; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute coronary syndrome; acute myocardial infarction; coronary artery disease; mortality; chronic total occlusion; pretreatment; antiplatelet; P2Y12; radial access; PCI; SWEDEHEART; SCAAR; RIKS-HIA; cardiology;

   Sammanfattning : Impact of chronic total occlusions, arterial access site and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry Background Treatment of ischemic heart disease has advanced substantially in the past half-century. However, despite these achievements the survival rates in high-income countries such as Sweden have reached a plateau in the last decade. LÄS MER

7. 5. Tumor-stroma interactions in hepatocellular carcinoma

   Författare :Nataša Pavlović; Femke Heindryckx; Jessica Maiers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatocellular carcinoma; fibrosis; endoplasmic reticulum stress; unfolded protein response; platelets; P2Y12; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Hepatocellular carcinoma (HCC), a highly deadly primary liver cancer with a rising global incidence and limited therapeutic options, is characterized by a vicious cross-talk between the tumor and its surrounding hepatic stroma. The stromal environment, consisting of hepatic stellate cells (HSC), endothelial cells, resident and infiltrating macrophages and other immune cells, platelets and extracellular matrix (ECM) components, actively contributes to creating an ideal niche for tumor proliferation and invasiveness. LÄS MER