Sökning: "Uppsala model"

Visar resultat 11 - 15 av 2483 avhandlingar innehållade orden Uppsala model.

  1. 11. Covariate Model Building in Nonlinear Mixed Effects Models

    Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

  3. 12. Model Checking Parameterized Timed Systems

    Författare :Pritha Mahata; Parosh Abdulla; Jean-Francois Raskin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Model Checking; Parameterized Systems; Undecidability; Timed Petri Nets; Timed Networks; Computer science; Datavetenskap;

    Sammanfattning : In recent years, there has been much advancement in the area of verification of infinite-state systems. A system can have an infinite state-space due to unbounded data structures such as counters, clocks, stacks, queues, etc. It may also be infinite-state due to parameterization, i.e. LÄS MER

  4. 13. Improvement and Assessment of Two-Dimensional Resistivity Models Derived from Radiomagnetotelluric and Direct-Current Resistivity Data

    Författare :Thomas Kalscheuer; Laust B. Pedersen; Christopher Juhlin; Roland Roberts; Heinrich Brasse; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Electromagnetic geophysics; radiomagnetotellurics; direct-current resistivity; displacement currents; dielectric effect; non-linearity; inversion; regularization; two-dimensional model; model variance; model resolution; data resolution; Geophysics; Geofysik;

    Sammanfattning : Two-dimensional (2-D) models of electrical resistivity are improved by jointly inverting radiomagnetotelluric (RMT) and direct-current resistivity (DCR) data or by allowing for displacement currents in the inversion of RMT data collected on highly resistive bedrock. Uniqueness and stability of the 2-D models are assessed with a model variance and resolution analysis that allows for the non-linearity of the inverse problem. LÄS MER

  5. 14. Fragmentation in Proton-Nucleus Reactions from 100 to 1400 MeV

    Författare :Henrik Jäderström; Lars Wesretberg; Yuri Murin; Kjell Aleklett; Haik Simon; Uppsala universitet; []
    Nyckelord :Nuclear physics; proton; deuteron; 20Ne; 28Si; Xe; nuclear reactions; inverse kinematics; recoils; intermediate mass fragments; angular distribution; DCM model; JQMD model; CFEM model; single event upset; Kärnfysik;

    Sammanfattning : The heaviest fragments, recoils, have been studied in proton and deuteron induced 28Si reactions and proton-20Ne reactions at 100-300 MeV per nucleon. Inclusive charge and angular distributions and coincidences between He nuclei and recoils have been compared to two theoretical models, Dubna Cascade Model and JAERI Quantum Molecular Dynamics. LÄS MER

  7. 15. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

    Författare :Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). LÄS MER