Sökning: "Least absolute shrinkage and selection operator"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Least absolute shrinkage and selection operator.

1. 1. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics

   Författare :Emmy Borgmästars; Malin Sund; Ola Billing; Pär Jonsson; Zelmina Lubovac-Pilav; Oskar Franklin; Stefan Enroth; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pancreatic cancer; microRNA functional analysis; TPS; miRNomics; metabolomics; proteomics; plasma samples; early detection; risk; survival;

   Sammanfattning : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. LÄS MER

3. 2. Covariate Model Building in Nonlinear Mixed Effects Models

   Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
   Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

   Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

4. 3. Spatial Characterization and Estimation of Intracardiac Propagation Patterns During Atrial Fibrillation

   Författare :Ulrike Richter; Institutionen för elektro- och informationsteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electrogram; Atrial Fibrillation; Propagation Pattern Analysis; Biomedical Signal Processing;

   Sammanfattning : This doctoral thesis is in the field of biomedical signal processing with focus on methods for the analysis of atrial fibrillation (AF). Paper I of the present thesis addresses the challenge of extracting spatial properties of AF from body surface signals. LÄS MER

5. 4. Parameter Estimation and Filtering Using Sparse Modeling

   Författare :Ashkan Panahi; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; sparsity based tracking; Sparsity based techniques; off-grid effect; parameter estimation; continuous basis pursuit; compressed sensing;

   Sammanfattning : Sparsity-based estimation techniques deal with the problem of retrieving a data vector from an undercomplete set of linear observations, when the data vector is known to have few nonzero elements with unknown positions. It is also known as the atomic decomposition problem, and has been carefully studied in the field of compressed sensing. LÄS MER

7. 5. Parameter Estimation Using Sparse Modeling: Algorithms and Performance Analysis

   Författare :Ashkan Panahi; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; compressed sensing; linear regression; spatial sparsity; convex variational optimization; DOA estimation; continuous LASSO; Complex LASSO;

   Sammanfattning : The idea of representing a signal in a classical computing machine has played a central role in the field of signal processing. The last two decades have witnessed an important breakthrough in this by taking all possible linear transforms and domains into account. LÄS MER