Sökning: "Tumour inhibition"

Visar resultat 11 - 15 av 97 avhandlingar innehållade orden Tumour inhibition.

  1. 11. Medical, cognitive and motor outcome after treatment of pilocytic astrocytoma in the posterior fossa in childhood

    Författare :Ingela Kristiansen; Per Frisk; B Strömberg; Klas Blomgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood; CNS tumour; pilocytic astrocytoma; posterior fossa; long-term outcome; cognition; language; motor performance; learning difficulties; Pediatrik; Pediatrics;

    Sammanfattning : Introduction: Pilocytic astrocytoma is the most common brain tumour in childhood. The aim of the studies was to investigate late medical, cognitive and motor complications in patients treated in childhood for pilocytic astrocytoma in the posterior fossa. LÄS MER

  3. 12. Growth control mechanisms in normal and neoplastic mammalian cells

    Författare :Mozhgan Afrakhte; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; PDGF-AA; TGF-beta; Inhibitory SMADs; Growth inhibition; CDK; CKI; Cdc25A; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

    Sammanfattning : The main theme of the studies presented in this thesis is, the growth control mechanisms whose loss in normal cells predispose to or cause cancer. The balance between growth inhibitory and stimulatory mechanisms is crucial for the development and maintenance of a normal animal. LÄS MER

  4. 13. Exploring novel therapeutic strategies in neuroblastoma

    Författare :Joanna Szydzik; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neuroblastoma; Anaplastic Lymphoma Kinase; Targeted therapy; ATR inhibition;

    Sammanfattning : Neuroblastoma (NB) is the most frequently diagnosed extracranial tumour in children, which arises from transient embryonal tissue of the neural crest that fails to complete terminal differentiation into neurons. Even after completion of successful therapy, high risk neuroblastoma patients typically suffer from post-treatment induced toxicity which impacts on their ability to lead a normal life. LÄS MER

  5. 14. Extracellular Matrix and Connective Tissue Cells of the Tumor Microenvironment

    Författare :Tomas Friman; Christian Sundberg; Kristofer Rubin; Ulf Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Tumour biology; Tumörbiologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : In addition to malignant cells, solid tumors comprise supporting stromal tissue that consists of extra cellular matrix (ECM), connective tissue cells, inflammatory cells and blood vessels. The stromal compartment and the malignant cells together shape the tumor microenvironment that in turn determines tumor progression and efficacy of anti-tumor treatments. LÄS MER

  7. 15. Pharmacological Studies of CHS 828 and Etoposide Induced Tumour Cell Death

    Författare :Petra Martinsson; Stig Linder; Uppsala universitet; []
    Nyckelord :Medical sciences; Cancer chemotherapy; cell death; caspase; etoposide; CHS 828; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Antitumour properties of the cyanoguanidine CHS 828 and analogues were discovered in 1997. CHS 828 is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U-937 GTB, by CHS 828 and the standard antitumour drug etoposide. LÄS MER