Sökning: "Topoisomerase IV"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Topoisomerase IV.

  1. 1. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Författare :Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Nyckelord :Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Sammanfattning : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. LÄS MER

  3. 2. Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae

    Författare :Emma Lindbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neisseria gonorrhoeae; ciprofloxacin; DNA-gyrase; topoisomerase IV; major outer membrane protein;

    Sammanfattning : A few years ago, most strains of Neisseria gonorrhoeae were susceptible to ciprofloxacin, but after introduction as a first line therapy, resistant strains emerged. Ciprofloxacin inhibit two enzymes necessary for DNA replication. LÄS MER

  4. 3. Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens

    Författare :Herin Oh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Quinolone; resistance; B. fragilis; P. aeruginosa; topoisomerase; efflux;

    Sammanfattning : Opportunistic pathogens can cause infections in case of structural or functional defects in the host. Examples of Gram-negative opportunists are the Bacteroides fragilis group, anaerobic, non-spore forming rods and the aerobic, non-fermentative rod Pseudomonas aeruginosa. LÄS MER

  5. 4. Studies on anti-leukemic terpenoids from medicinal mushrooms and marine sponges with ChemGPS-NP-based targets investigation of lead compounds

    Författare :Kuei-Hung Lai; Anders Backlund; Christina Wedén; Fang-Rong Chang; Yang-Chang Wu; Nicholas Oberlies; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChemGPS-NP analysis; antileukemic agents; lanostanoids; sesterterpenoids; manoalide; Pharmacognosy; Farmakognosi;

    Sammanfattning : This thesis investigates the anti-leukemic activity of terpenoids isolated from medicinal mushrooms and marine sponges, as well as their possible targets and mechanisms of action.In the first section, we focused on studying the triterpenoidal components of three triterpenoid-enriched medicinal mushrooms Antrodia cinnamomea, Ganoderma lucidum, and Poria cocos, which have been used in folk medicine for centuries and also developed into several contemporary marketed products. LÄS MER

  7. 5. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Författare :Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Nyckelord :ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Sammanfattning : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. LÄS MER