Sökning: "Therapy resistance"

Visar resultat 21 - 25 av 436 avhandlingar innehållade orden Therapy resistance.

1. 21. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections

   Författare :Matti Karvanen; Otto Cars; Lena E Friberg; Vincent H Tam; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colistin; CMS; Pharmacology; Pharmacokinetics; PKPD; Antibiotics; Combination therapy; Pharmacometrics; Dosing regimens; Antibiotic resistance; Infectious Diseases; Infektionssjukdomar;

   Sammanfattning : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. LÄS MER

3. 22. Tumour Survival Signals and Epigenetic Gene Silencing in Multiple Myeloma : Implications for Biology and Therapy

   Författare :Charlotte Fristedt Duvefelt; Helena Jernberg-Wiklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Polycomb; apoptosis; cIAP2; IAP-inbibitors; proteasome inhibitors; LBH589; PPP; DZNep;

   Sammanfattning : This thesis is focused on multiple myeloma (MM), a haematological malignancy that still remains incurable. The pathogenesis of MM is not fully understood and there is a large intra-tumour and interclonal genetic variation in MM patients. LÄS MER

4. 23. Clinical aspects of restorative treatment in the primary dentition

   Författare :Mirja Varpio; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Child; Child; Preschool; Cohort Studies; Composite Resins; chemistry; DMF Index; Dental Caries; epidemiology; microbiology; pathology; therapy; Dental Cavity Preparation; classification; Dental Enamel; pathology; Dental Restoration; Permanent; statistics numerical data; Follow-Up Studies; Glass Ionomer Cements; chemistry; Humans; Molar; Prevalence; Prosthesis Failure; Recurrence; Sweden; epidemiology; Tooth; Deciduous;

   Sammanfattning : The failure rate of restorative treatment in primary teeth was studied in a cohort of children born in 1981 and related to caries diagnosis, prevalence and distribution on different tooth surfaces, and compared with a cohort of children born in 1971. Concurrently, the longevity of composite resin in modified Class 2 cavities in primary molars was followed up and the resistance of deciduous and permanent enamel to acid adjacent to composite resin and glass polyalkeonate cement (GPA) was tested in vitro. LÄS MER

5. 24. Vector development for suicide gene therapy

   Författare :Alar Aints; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

   Sammanfattning : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. LÄS MER

7. 25. Affibody-Based Molecular Imaging and Targeted Therapy of HER3-Expressing Cancer

   Författare :Sara Sophie Rinne; Anna Orlova; Vladimir Tolmachev; Mohamed Altai; Anzhelika Vorobyeva; Melpomeni Fani; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular Imaging; PET; SPECT; Cancer; Affibody; HER3; Targeted Therapy;

   Sammanfattning : The human epidermal growth factor receptor type 3 (HER3) is overexpressed in different types of cancer and is a known contributor to disease progression and resistance to cancer therapy. This thesis is based on five original articles, which aimed to improve the diagnostic and therapeutic potential of affibody-based agents for management of HER3-expressing cancers. LÄS MER