Sökning: "TNF antagonists"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden TNF antagonists.

  1. 1. Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects

    Författare :Meliha C Kapetanovic; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skelett; muskelsystem; reumatologi; Skeleton; muscle system; rheumatology locomotion; ANA; infusion reaction; influenza vaccination; pneumococcal vaccination; COMP; TNF antagonists; spondylarthropathies; arthritis; rheumatoid arthritis;

    Sammanfattning : Abstract The treatment of arthritis has undergone a dramatic change since biological agents targeting specific mediators of the disease process have been introduced. Tumour necrosis factor (TNF) antagonists have been shown to reduce signs and symptoms of disease and to retard the development of tissue damage in the majority of patients. LÄS MER

  3. 2. Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability

    Författare :Lars Erik Kristensen; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; response; drug survival; psoriatic arthritis; Arthritis; rheumatoid arthritis; adverse events; TNF antagonists;

    Sammanfattning : Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. LÄS MER

  4. 3. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Författare :Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. LÄS MER

  5. 4. Development of molecular recognition by rational and combinatorial engineering

    Författare :Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

    Sammanfattning : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. LÄS MER

  7. 5. MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia

    Författare :Aida Maddahi; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitogen activated protein kinase; iNOS; Matrix metalloproteinases; IL-1ß; IL-6; TNF-α; Inflammation; Subarachnoid hemorrhage; Middle cerebral artery occlusion;

    Sammanfattning : INTRODUCTION Stroke is a serious neurological disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. LÄS MER