Sökning: "RANKL"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet RANKL.

  1. 1. On the Role of Osteoprotegerin/RANK/RANKL System in the Interaction between Prostate Cancer and Bone

    Författare :Hendrik Penno; Östen Ljunggren; Olof Nilsson; Andreas Kindmark; Pernilla Lundberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metastases; bone; prostate cancer; osteoprotegerin; RANKL; osteoporosis; genetics; polymorphisms; Orthopaedics; Ortopedi;

    Sammanfattning : Metastases to bone are observed in around 80% of prostate cancer patients and represent the most critical complication of advanced prostate cancer. Unlike other solid tumors that are associated with osteolytic bone metastases, prostate cancer bone metastases stimulate osteoblastic activity with sclerosis in the bone lesions as a consequence. LÄS MER

  3. 2. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

    Författare :Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. LÄS MER

  4. 3. Kinins : important regulators in inflammation induced bone resorption

    Författare :Anna Bernhold Brechter; Ulf Lerner; Hans-Erik Claesson; Umeå universitet; []
    Nyckelord :Bone resorption; Osteoblasts; Kinins; B1 and B2 receptors; IL-1β; TNF-α; Prostaglandin; COX-2; RANKL; Transcription factors; IL-4; IL-13; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Inflammatory processes in, or in close vicinity of, the skeleton often lead to loss of bone tissue. Different cytokines have been shown to be involved as stimulators of inflammatory induced osteoclastic bone resorption. LÄS MER

  5. 4. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Författare :Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. LÄS MER

  7. 5. Immunopathogenic studies on inflammation and bone destruction in rheumatoid arthritis

    Författare :Shankar Kumar Revu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic systemic joint disease characterized by synovial inflammation, leading to destruction of cartilage and bone. Local recruitment of immune cells and defective apoptosis results in chronic inflammation with increased synovial citrullination and local hypoxia. LÄS MER