Sökning: "Secretory autoantibodies"

Hittade 5 avhandlingar innehållade orden Secretory autoantibodies.

  1. 1. Secretory Autoantibodies in Rheumatoid Arthritis

    Författare :Karin Roos Ljungberg; Alf Kastbom; Anna Svärd; Klara Martinsson; Jonas Wetterö; Per-Johan Jakobsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; Secretory autoantibodies; Immunoglobulins; Anti-citrullinated protein antibodies; ACPA; Mucosal immunity;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which autoantibodies, such as anti-citrullinated protein antibodies (ACPA), can be detected in the serum of patients. Autoantibodies may appear in the circulation years before clinical signs of joint inflammation occur, indicating that early immunological pathogenetic steps take place outside of the joints. LÄS MER

  3. 2. Immune mechanisms in atherosclerotic vascular disease

    Författare :Jasmina Cvetkovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; rheumatoid arthritis; stroke; autoantibodies; pro-inflammatory cytokines;

    Sammanfattning : Atherosclerosis has been categorized as an inflammatory disorder, with similar chronic inflammatory conditions found in rheumatoid arthritis. It entails an unregulated accumulation of lipids in the vessel wall, which leads to the development of cardiovascular diseases. LÄS MER

  4. 3. Immune mechanisms in atherosclerosis

    Författare :Ejaz Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; diabetes; stroke; rheumatoid arthritis; autoantibodies; anticardiolipin; oxidized LDL; hypercholesterolernia; IFN-gamma TNF-alpha IL-1beta IL-1Ra.;

    Sammanfattning : Atherosclerosis is a multifactorial chronic inflammatory disorder. Humoral immune factors as anticardiolipin antibodies (aCL), anti-oxLDL antibodies, circulating immune complexes (CICs), and proinflammatory cytokines such as IFN-gamma, TNF-alpha and EL-1beta have been implicated in atherogenesis. LÄS MER

  5. 4. Some Characteristics of Human Prostasomes and Their Relationship to Prostate Cancer

    Författare :Göran Ronquist; Anders Larsson; Lena Carlsson; Alicia Llorente; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostasomes; prostate; prostate cancer; clusterin; antibodies; metastasis; exosomes; PC-3 cells; DNA vehicles; gene therapy; immunoblotting; mass spectrometry; agarose gel electrophoresis; vertebral metastasis.; Clinical chemistry; Klinisk kemi; Clinical Chemistry; klinisk kemi;

    Sammanfattning : Background: The secretory epithelial cells of the prostate gland use sophisticated vehicles named prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. LÄS MER

  7. 5. Antibody- and osteoclast-dependent mechanisms of chronic pain

    Författare :Alexandra Jurczak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain is a frequent condition that affects approximately 20% of worldwide population with a higher prevalence among women. Due to the lack of optimal treatment, chronic pain leads to decreased life quality as well as significant physical and psychological complications. LÄS MER