Sökning: "QTL mice"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden QTL mice.

  1. 1. The Complex Genetics of Mouse Reproduction and Arhritis

    Författare :Maria Liljander; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; morula; B10.Q mice; genetics.; Pregnancy; CIA; reproduction; QTL; superovulation; blastocysts; oocytes; litter size; RA; NFR N mice; MHC;

    Sammanfattning : ABSTRACT Optimal breeding of mice is very important in biomedical science today. The understanding why some strains breed better and some worse enable scientists to create better in vivo models for human diseases. LÄS MER

  3. 2. Identification of Arthritis Susceptibility Genes in Mice and Humans

    Författare :Emma Ahlqvist; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; Biomedicinska vetenskaper; QTL; Biomedical sciences; Rheumatoid arthritis; Collagen-induced arthritis; serologi; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Clinical genetics; Klinisk genetik;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune disease with a largely unknown aetiology. The risk of developing RA is partly dependent on genetic factors, which has motivated extensive efforts to identify the disease regulating genes as away to understand disease pathogenesis. LÄS MER

  4. 3. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models

    Författare :Carl-Johan Rubin; Andreas Kindmark; Östen Ljunggren; Leif Andersson; David Burt; Uppsala universitet; []
    Nyckelord :Molecular medicine; QTL; Bone; Osteoporosis; Gene expression; Microarray; Domestication; Molekylärmedicin;

    Sammanfattning : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. LÄS MER

  5. 4. Genetic characterization to dissect the phenotypic complexity of autoimmunity

    Författare :Jenny C Karlsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; epistasis; EAE; autoimmunity; Immunology; CIA; QTL;

    Sammanfattning : Autoimmune diseases are dependent on multiple genes and unknown environmental factors. Great efforts in the identification of genes conferring susceptibility to autoimmune diseases like Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS) have recently been rewarding. LÄS MER

  7. 5. Genetic and genomic analysis of arthritis regulating regions in human and mouse

    Författare :Lina Olsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Immunologi; serologi; transplantation; Skeleton; muscle system; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; QTL; NADPH oxidase complex; Rheumatoid Arthritis; Genetic Analysis;

    Sammanfattning : Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. LÄS MER