Sökning: "B10.Q mice"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden B10.Q mice.

  1. 1. The Complex Genetics of Mouse Reproduction and Arhritis

    Författare :Maria Liljander; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; morula; B10.Q mice; genetics.; Pregnancy; CIA; reproduction; QTL; superovulation; blastocysts; oocytes; litter size; RA; NFR N mice; MHC;

    Sammanfattning : ABSTRACT Optimal breeding of mice is very important in biomedical science today. The understanding why some strains breed better and some worse enable scientists to create better in vivo models for human diseases. LÄS MER

  3. 2. Analysis of effector pathways in arthritis

    Författare :Nandakumar Kutty Selva; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; Genetik; cytogenetics; Arthritis; mice; monoclonal antibody; collagen type II; Histology; histochemistry; cytochemistry; Histologi; tissue culture; cytokemi; histokemi; Genetics; vävnadskultur; serologi; cytogenetik; Immunology; serology;

    Sammanfattning : Rheumatoid arthritis (RA) is a multifactorial, polygenic autoimmune disease. For effective treatment and control of RA, understanding of disease pathways and identification of genes involved are essential. Animal models are efficient tools to identify such pathogenic mechanisms and genes underlying the disease process. LÄS MER

  4. 3. Finding genes controlling arthritis in mice-Fcγ receptors and complement C5

    Författare :Dorota Klaczkowska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are dependent on multifactorial factors including genes, environment and interactions between them. This thesis is focused on a chronic inflammatory disorder, Rheumatoid arthritis (RA). So far only very few genes and environmental factors have been identified reflecting the complexity of the autoimmune processes. LÄS MER

  5. 4. Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice

    Författare :Simon Guérard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and eventually invalidity if left untreated. LÄS MER

  7. 5. T cells, Cytokines, and Genetic Factors in Autoimmunity Studies of experimental models of arthritis and sialadenitis

    Författare :Åsa Johansson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Collagen-induced arthritis Sialadenitis Mice Knockout Linkage analysis T cells Cytokines; muscle system; Skeleton; reumatologi; muskelsystem; Skelett;

    Sammanfattning : To understand the pathogenesis of autoimmune diseases we have to consider the problem from different angles. Animal models provide a tool to further understand these complex diseases, as the influence of genetic and environmental factors could be limited. LÄS MER