Sökning: "Phenotypic Characterization"

Visar resultat 16 - 20 av 74 avhandlingar innehållade orden Phenotypic Characterization.

1. 16. In vitro and in vivo approaches in the characterization of XTH gene products

   Författare :Nomchit Kaewthai; Harry Brumer; Jocelyn Rose; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Arabiodopsis thaliana; Hordeum vulgare; plant cell wall; xyloglucan; glycoside hydrolase family 16; xyloglucan endo-transglycosylase hydrolase gene family; xyloglucan endo-hydrolase; heterologous protein expression; Pichia pastoris; T-DNA insertion; in situ XET XEH assay; high-througput screening; Plant physiology; Växtfysiologi; Biochemistry; Biokemi; Functional genomics; Funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Sammanfattning : ABSTRACT The xyloglucan endo-transglycosylase/hydrolase (XTH) genes are found in all vascular and some nonvascular plants. The XTH genes encode proteins which comprise a subfamily of glycoside hydrolase (GH) family 16 in the Carbohydrate-Active enZYmes (CAZY) classification. LÄS MER

3. 17. Characterization of the in vivo mechanisms of action of cell envelope-targeting antibiotics

   Författare :Ann-Britt Schäfer; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mode of action; antimicrobial peptides; cell-envelope targeting; antibiotics;

   Sammanfattning : Multidrug-resistant bacteria pose a major threat to society. Once easily treatable diseases are now challenging to cure. With the golden age of antibiotics being over, the discovery of new antibiotics has been stagnant, and no new antibiotic class has been introduced into the clinic since 2003. LÄS MER

4. 18. Functional characterization of the biological significance of the ZBED6/ZC3H11A locus in placental mammals

   Författare :Shady Younis; Leif Andersson; Ola Hansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; IGF2; ZC3H11A; Muscle development; Transcriptome analysis; CRISPR Cas9; mRNA export; Molekylär genetik; Molecular Genetics; Bioinformatik; Bioinformatics;

   Sammanfattning : The recent advances in molecular and computational biology have made possible the study of complicated transcriptional regulatory networks that control a wide range of biological processes and phenotypic traits. In this thesis, several approaches were combined including next generation sequencing, gene expression profiling, chromatin and RNA immunoprecipitation, bioinformatics and genome editing methods in order to characterize the biological significance of the ZBED6 and ZC3H11A genes. LÄS MER

5. 19. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

   Författare :Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. LÄS MER

7. 20. Analysis of Complement Deficiency States. With Focus on Molecular Characterization of C4 and Properdin Deficiency

   Författare :Gunilla Nordin Fredrikson; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycology; virology; bacteriology; Complement C4; Complement; Complement Screening; Deficiency; Meningococcal Disease; Properdin; Properdin Expression; Microbiology; Sequencing; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : Complement deficiency is associated with an increased risk for invasive infection and immune complex disease. Screening for identification of complement-deficient patients is essential and a new ELISA-based procedure for detection of complement deficiency is described. LÄS MER