Sökning: "cell-envelope targeting"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden cell-envelope targeting.

  1. 1. Characterization of the in vivo mechanisms of action of cell envelope-targeting antibiotics

    Författare :Ann-Britt Schäfer; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mode of action; antimicrobial peptides; cell-envelope targeting; antibiotics;

    Sammanfattning : Multidrug-resistant bacteria pose a major threat to society. Once easily treatable diseases are now challenging to cure. With the golden age of antibiotics being over, the discovery of new antibiotics has been stagnant, and no new antibiotic class has been introduced into the clinic since 2003. LÄS MER

  3. 2. Protein production in the E. coli cell envelope

    Författare :Thomas Baumgarten; Jan-Willem de Gier; Dirk-Jan Scheffers; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; E. coli; protein biogenesis; recombinant proteins; membrane proteins; secretory proteins; protein displays; outer membrane vesicles; Biochemistry; biokemi;

    Sammanfattning : Proteins fulfil essential functions in every cell and malfunctioning proteins are often the cause of diseases. On the other hand, proteins like antibody fragments or hormones can be used to treat diseases. LÄS MER

  4. 3. Targeting cell envelope synthesis of Streptococcus pneumoniae and microfluidic diagnostic tool development

    Författare :Elisabeth Reithuber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Evolving antibiotic resistance warrants the development of new therapeutic and diagnostic approaches as part of the strategies to secure future antibacterial therapies and preserve the compounds currently available. Work constituting the thesis characterized small molecules yielded from a screen for autolysis inducing compounds on Streptococcus pneumoniae. LÄS MER

  5. 4. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins

    Författare :Adrian Suarez Covarrubias; Sherry Mowbray; Torsten Unge; Pedro Alzari; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; carbonic anhydrase; threonine synthase; FAS II; Rv0636; Rv1284; Rv1295; Rv3588c; Rv3778c; X-ray crystallography; Cell- och molekylärbiologi; Mycobacterium tuberculosis;

    Sammanfattning : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. LÄS MER

  7. 5. Structural basis of cysteine biosynthesis and peptidoglycan remodelling in Mycobacterium tuberculosis

    Författare :Dominic Böth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mycobacterium tuberculosis is the causative agent of tuberculosis, which is responsible for 1.3 million deaths annually. Treatment is difficult due to an elaborate defense machinery, which includes specific metabolic changes of the bacilli upon exposure to antibiotics and the immune response of the host. LÄS MER