Sökning: "Phenotypic Characterization"
Visar resultat 21 - 25 av 74 avhandlingar innehållade orden Phenotypic Characterization.
21. Structural pathology and functional analysis of vitamin K-dependent protein S
Sammanfattning : Protein S deficiency is an autosomal dominant trait affecting around 10% of families thrombophilic families. The high affinity interaction of approximately 60% of protein S with C4b -binding protein (C4BP) has raised a complicated situation for the diagnosis of deficiency states. LÄS MER
22. Identification of novel modulators of protein synthesis and nucleolar biology using high throughput phenotypic screens
Sammanfattning : Protein synthesis and ribosome biogenesis are fundamental steps in gene expression and constitute the most energy demanding processes in living cells. Dysregulation of these processes is associated to a variety of human disorders including cancer, metabolic diseases, immunodeficiency, neurological and developmental disorders, and physiological aging. LÄS MER
23. Novel diagnostic methods for rapid characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae
Sammanfattning : Klebsiella pneumoniae and Escherichia coli are two of the most clinically important pathogens of the family Enterobacteriaceae. Both can cause severe infections includ-ing urinary tract infections (UTI), bloodstream infections (BSI) and pneumonia. Both are also involved in dissemination of antibiotic resistance. LÄS MER
24. Ontogenetic Characterization of Müllerian Duct Development and Expression of anti-Müllerian hormone and Other Genes : New Endpoints in the Frog Xenopus tropicalis Test System
Sammanfattning : The amphibian model-species Xenopus tropicalis is used in reproductive toxicology studies. Lifecycle studies are requested but they are time consuming and susceptible to several of the risks attributed to long-term studies. LÄS MER
25. Robustness quantification in yeast: A methodology to study phenotypic, evolutionary, and genomic aspects of microbial robustness
Sammanfattning : Bioprocesses contribute to the shift towards a more sustainable economy. In bioprocesses, valuable chemicals can be generated from renewable resources while, at the same time, reducing carbon emissions. A major hurdle in bringing bio-based products to market is the time and cost involved in designing efficient cell factories. LÄS MER