Sökning: "O-antigen"

Visar resultat 6 - 10 av 32 avhandlingar innehållade ordet O-antigen.

1. 6. Prediction of 3D structures of oligosaccharides. Methodological development and studies on saccharide antigens of interest for vaccine design

   Författare :Jimmy Rosen; Göteborgs universitet; []
   Nyckelord :Oligosaccharide; conformation; 3D structure; O-antigen; Shigella dysenteriae; Escherichia coli; Burkholderia cepacia; Schistosoma mansoni; filtered systematic search; genetic algorithm;

   Sammanfattning : This thesis presents 3D structure predictions of five immunologically active surfacepolysaccharides of pathogens, which are of interest as targets for development of glycoconjugatevaccines. Furthermore it describes two methods which have been used for theconformational predictionsThe Shigella dysenteriae type 2 Oantigenwas predicted to form a compact helicalstructure with three repeating pentasaccharide units per turn. LÄS MER

3. 7. Structure Elucidations of Bacterial Polysaccharides using NMR Spectroscopy and Bioinformatics

   Författare :Jonas Ståhle; Göran Widmalm; Evgeny Vinogradov; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Bioinformatics; NMR Spectroscopy; Lipopolysaccharide; Glycosyltransferase; Computer-Assisted Structure Elucidation; O-antigen; Biosynthesis; Organic Chemistry; organisk kemi;

   Sammanfattning : Carbohydrates are ubiquitous components in nature involved in a range of tasks. They cover every cell and contribute both structural stability as well as identity. Lipopolysaccharides are the outermost exposed part of the bacterial cell wall and the primary target for host-pathogen recognition. LÄS MER

4. 8. Structural elucidation of the O-antigen polysaccharides of five Escherichia coli strains

   Författare :Malin Linnerborg; Yuriy A. Knirel; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

   Sammanfattning : The cell walls of bacteria are composed to a large extent of different polysaccharides. In order to understand and thereby, be able to utilise the physical, biological and immunological properties of polysaccharides, it is important to determine their structures. LÄS MER

5. 9. NMR spectroscopy in structural and conformational analysis of bacterial polysaccharides

   Författare :Carolina Fontana; Göran Widmalm; Sven Müller-Loennies; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear Magnetic Resonance; carbohydrates; O-antigen polysaccharide; organisk kemi; Organic Chemistry;

   Sammanfattning : Carbohydrates constitute one of the three major classes of biomolecules found in all living cells and, unlike nucleic acids and proteins, their polymeric structures are not based on a template. The structural diversity of these molecules confers them an enormous capacity to encode information in biological systems, acting as efficient mediators in the interaction of the cell with the environment. LÄS MER

7. 10. Glucosyl transferase gene(s) of temperate bacteriophages SfX and SfV and their role in the modification of the O-antigen of Shigella flexneri

   Författare :Pham Thi Huan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Shigella flexneri is the main cause of bacillary dysentery in developing countries with a high attack rate and mortality in young children. Thus developing a S. flexneri vaccine has been given priority by WHO. It has been documented that Shigella lipopolysaccharide (LPS) is highly immunogenic. LÄS MER