Sökning: "Glycosyltransferase"

Visar resultat 1 - 5 av 39 avhandlingar innehållade ordet Glycosyltransferase.

  1. 1. Biochemical studies of carbohydrate blood group antigens - Carbohydrate phenotype in relation to cellular glycosyltranferases

    Författare :Mette Diswall; Göteborgs universitet; []
    Nyckelord :glycosphingolipid; glycosyltransferase; genetic modification; carbohydrate; mass spectrometry; proton NMR spectroscopy; xenotransplantation; GalT-KO pig;

    Sammanfattning : The possibility to alter the cell surface carbohydrate expression by insertion or deletion of glycosyltransferase genes is a powerful technique to study the biological function of selected carbohydrate antigens. However, shifting the equilibrium between competing glycosyltransferases might lead to unexpected phenotypic effects, such as accumulation of other carbohydrate antigens and exposure of antigen structures that normally are cryptic or present in minute amounts on the cell surface. LÄS MER

  3. 2. Structural and biochemical insights into biosynthesis and degradation of N-glycans

    Författare :Tom Reichenbach; Christina Divne; David Drew; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; N-glycan; biosynthesis; degradation; glycosyltransferase; glycoside hydrolase; biofuel; enzyme; membrane protein; Bioteknologi; Biotechnology;

    Sammanfattning : Carbohydrates are a primary energy source for all living organisms, but importantly, they also participate in a number of life-sustaining biological processes, e.g. cell signaling and cell-wall synthesis. The first part of the thesis examines glycosyltransferases that play a crucial role in the biosynthesis of N-glycans. LÄS MER

  4. 3. Enzymes involved in heparan sulfate chain elongation : Function of a novel family of tumor suppressors?

    Författare :Thomas Lind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; biosynthesis; glycosyltransferase; EXT1; EXT2; UDP-glucosedehydrogenase; KfiC; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan associated with many physiological functions such as regulation of growth factor action and cell adhesion. The HS polysaccharide is synthesized by alternating addition of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (GlcNAc) units from the corresponding UDP-sugar precursors. LÄS MER

  5. 4. Structure, dynamics and interactions of biomolecules : Investigations by NMR spectroscopy and computational methods

    Författare :Jens Landström; Göran Widmalm; Pedro Nieto; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; MD simulation; carbohydrate synthesis; protein-ligand interaction; glycosyltransferase; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, the structure, dynamics and interactions of proteins and carbohydrates are investigated using mainly NMR spectroscopy and computer simulations. Oligosaccharides representing a Salmonella O-antigen have been synthesized and their dynamic behavior and interaction with the bacteriophage P22 tail-spike protein have been studied by NMR spectroscopy, MD and docking simulations. LÄS MER

  7. 5. Studies on the genetic basis of Pk, P and P1 blood group antigen expression

    Författare :Åsa Hellberg; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serology; serologi; transplantation; Immunology; SNP; phenotype; erythrocyte; blood group; glycosyltransferase;

    Sammanfattning : The clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. LÄS MER