Sökning: "Non-classical genes"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden Non-classical genes.

  1. 6. Pinpointing biomarkers of importance for children with combined type 1 diabetes and celiac disease

    Författare :Andrea Tompa; Maria Faresjö; Karin Åkesson; Mikael Karlsson; Jönköping University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; celiac disease; children; biomarkers; immune markers; flow cytometry; cryopreservation; T cells; T-regulatory cells; B cells; B-regulatory cells; cytokines; chemokines; acute phase proteins; adipocytokines; matrix metalloproteinases;

    Sammanfattning : Type 1 diabetes (T1D) and celiac disease are both characterized by an autoimmune feature. The diseases also share the same risk genes, and thereby patients have an increased risk of developing the other disease subsequently. LÄS MER

  3. 7. Origin and ontogeny of human lung macrophages

    Författare :Elza Evren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. LÄS MER

  4. 8. Monocytes and macrophages, with a focus of Crohn's disease

    Författare :Susanne Thiesen; Internmedicin - epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Crohn s disease; Cystatin C; Cytokines; Intestine; Macrophages; Monocytes; Gene-expression;

    Sammanfattning : Monocytes and macrophages are part of the body’s first line of defense, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines and proteases. In humans, three subsets of monocytes are described with seemingly different functions. LÄS MER

  5. 9. Toxicological studies of di-n-butyl phthalate (DBP) : Impact on the reproductive system and gut microbiota

    Författare :Radwa Almamoun; Oskar Karlsson; Paula Pierozan; Harri Alenius; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dibutyl phthalate; Antiandrogen; Gut microbiota; Reproductive toxicity; Endocrine disrupting chemicals; Environmental contaminants; Phthalates; Plastics; 3D cell culture model; Exposome; Toxicology; Environmental Sciences; miljövetenskap;

    Sammanfattning : The potential health impact of exposure to anthropogenic chemicals has raised major concerns worldwide. Phthalates are mainly used in the plastic industry and have been associated with adverse effects in humans. Di-n-butyl phthalate (DBP) is one of the dominant phthalates with a ubiquitous presence in the environment. LÄS MER

  7. 10. Modulation of hormone signaling by cadmium : from molecular mechanisms to health implications

    Författare :Imran Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cadmium is a toxic metal classified as human carcinogen and ubiquitously found in our environment mainly from anthropogenic activities. Exposure to cadmium has been associated with increased risk of certain hormone-dependent cancers in humans, and the metal has been proposed to possess endocrine disruptive properties by mimicking the physiological actions of estrogens. LÄS MER