Sökning: "Neurochemistry with Molecular Neurobiology"

Visar resultat 11 - 15 av 77 avhandlingar innehållade orden Neurochemistry with Molecular Neurobiology.

  1. 11. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies

    Författare :Mats Hansen; Ülo Langel; Mark Lindsay; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptides; mechanisms; toxicity; structure-activity relationship; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. LÄS MER

  3. 12. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis

    Författare :Moataz Dowaidar; Ülo Langel; Sandrine Sagan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; magnetic nanoparticles; graphene oxide; autophagy; siRNA; SCO; QSAR; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. LÄS MER

  4. 13. Characterization of the inner nuclear membrane protein Samp1, during interphase and mitosis

    Författare :Veronica J. Larsson; Einar Hallberg; Katharine S. Ullman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Samp1; LINC complex; nuclear lamina; MCLIP; nuclear envelope; spindle assembly; spindle stability; k-fiber; gamma tubulin; Aurora B; Haus6; Augmin; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The nucleus, a hallmark in eukaryotic cells, contains the genome separating it from molecules in the cytoplasm. The nucleus is surrounded by a nuclear envelope consisting of two concentric membranes, the outer nuclear membrane and the inner nuclear membrane, the nuclear lamina and nuclear pore complexes. LÄS MER

  5. 14. Studies on Human and Drosophila melanogaster Glutathione Transferases of Biomedical and Biotechnological Interest

    Författare :Aslam M.A. Mazari; Bengt Mannervik; Philip Board; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; glutathione transferases; detoxication; hpgds inhibition; immobilization; isothiocyanates; drosophila GSTs; environmental pollutants; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Glutathione transferases (GSTs, EC.2.5.1. LÄS MER

  7. 15. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

    Författare :Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. LÄS MER