Sökning: "detoxication"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet detoxication.

  1. 1. Studies on Human and Drosophila melanogaster Glutathione Transferases of Biomedical and Biotechnological Interest

    Författare :Aslam M.A. Mazari; Bengt Mannervik; Philip Board; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; glutathione transferases; detoxication; hpgds inhibition; immobilization; isothiocyanates; drosophila GSTs; environmental pollutants; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Glutathione transferases (GSTs, EC.2.5.1. LÄS MER

  3. 2. Alpha-class Glutathione Transferases from Pig: a Comparative Study

    Författare :Natalia Fedulova; Bengt Mannervik; Francoise Raffalli-Mathieu; Mario Lo Bello; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; substrate selectivity; steroidogenesis; Sus scrofa; functional comparison; irreproducibility; reproducible assays; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Glutathione transferases (GSTs, EC 2.5.1.18) possess multiple functions and have potential applications in biotechnology. LÄS MER

  4. 3. Catalysis by theta-class glutathione transferases : Substrate binding, product formation and product release

    Författare :Per Jemth; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Glutathione transferases (GSTs) are detoxication enzymes that catalyze theconjugation of glutathione to a large number of electrophilic molecules. In this waythey help to rid cells of potentially toxic substances. This thesis deals with thecatalysis afforded by Theta-class glutathione transferases. LÄS MER

  5. 4. Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis

    Författare :Sanela Kurtovic; Bengt Mannervik; Ulf Hellman; Denis Pompon; Uppsala universitet; []
    Nyckelord :Biochemistry; DNA shuffling; substrate selectivity; mutant library; glutathione transferase; multivariate data analysis; prodrug; Biokemi;

    Sammanfattning : Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. LÄS MER

  7. 5. Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering

    Författare :Usama M. Hegazy; Bengt Mannervik; Mikael Widersten; T. J. Mantle; Uppsala universitet; []
    Nyckelord :Biochemistry; Glutathione transferase; targeted chemical modification; lock-and-key motif; cooperativity; stucture-function relationship; protein engineering; unnatural amino acid; site-specific mutation; Biokemi;

    Sammanfattning : The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of GSTP1-1. LÄS MER